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US 2003/0171397 A1Published application
Potentiation of antineoplastic agents using sigma-2
OwnerKeith W. Crawford, Wayne D. Boweninventors
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Abstract
The present invention relates to the use of sigma-2 agonists to potentiate the activity of antineoplastic agents. These substances are useful for treating cancerous tumors and, in particular, drug resistant tumors in humans. Methods for sensitizing multidrug resistant cells to antitumor agents comprising contacting the cells with a sigma-2 agonist are also described.
Claims18
A method for potentiating an antineoplastic effect of a DNA-damaging antineoplastic agent on a cancer cell, comprising contacting the cancer cell with a subtoxic amount of a sigma-2 agonist and an effective amount of said DNA-damaging antineoplastic agent.
Dependencies are inferred from the claim text.