Small molecules for the treatment of abnormal cell growth
AssigneePfizer Inc.
InventorsRichard D. Connell, John C. Kath, James D. Moyer
Life of this patent
Estimating the term…
Abstract
This invention relates to small molecules that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such small molecules in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds. The invention further relates to small molecules that are selective for erbB2 receptor over the erbB1 receptor, wherein said erbB2 inhibitor has a range of selectivities for erbB2 over erbB1 between 50-1500.
Claims99
A small molecule erbB2 inhibitor, wherein said erbB2 inhibitor has a range of selectivities for erbB2 over erbB1 between 50-1500.
A small molecule erbB2 inhibitor, wherein said erbB2 inhibitor has a range of selectivities for erbB2 over erbB1 between 50-1500 and inhibits growth of tumor cells which overexpress erbB2 receptor in a patient treated with a therapeutically effective amount of said erbB2 inhibitor.
A method of treating abnormal cell growth in a mammal comprising administering to said mammal an amount of a small molecule erbB2 inhibitor that is effective in treating abnormal cell growth and said erbB2 inhibitor has a range of selectivities for erbB2 over erbB1 between 50-1500.
The method of claim 46, wherein said erbB2 inhibitor has an IC50 of less than about 50 nM.
The method of claim 48, wherein said erbB2 inhibitor has an IC50 of less than about 50 nM.
The method of claim 50, wherein said erbB2 inhibitor has an IC50 of less than about 50 nM.
A method of treating abnormal cell growth in a mammal comprising administering to said mammal a small molecule erbB2 inhibitor in an amount that is effective in treating abnormal cell growth and said erbB2 inhibitor has a range of selectivities for erbB2 over erbB1 between 50-1500 as measured by an in vitro cell assay.
A method for treating a mammal having a disease characterized by an overexpression of erbB2, comprising administering to the mammal a small molecule erbB2 inhibitor in an amount that is effective in treating a disease characterized by the overexpression of erbB2 and said erbB2 inhibitor has a range of selectivities for erbB2 over erbB1 between 50-1500.
A method for treating a mammal having cancer characterized by an overexpression of erbB2, comprising administering to the mammal a small molecule erbB2 inhibitor in an amount that is effective in treating said cancer characterized by the overexpression of erbB2 and said erbB2 inhibitor has a range of selectivities for erbB2 over erbB1 between 50-1500.
A method for inducing cell death comprising exposing a cell which overexpresses ErbB2 to an effective amount of an erbB1-sparing erbB2 inhibitor.
A method of treating cancer in a human, wherein the cancer expresses the erbB2 receptor, comprising administering to the human a therapeutically effective amount of an erbB2 inhibitor that has reduced affinity for the erbB1 receptor.
Dependencies are inferred from the claim text.