Methotrexate derivatives

Abstract

Antirheumatic agent containing as an active ingredient a compound resented by the following general formula (II): 1 {where W is a group represented by the general formula: 2 [where R1 is a lower alkyl group having 1-4 carbon atoms; R2 is a lower alkyl group having 1-4 carbon atoms or a trifluoromethyl group; R3 is a hydrogen atom, a lower alkyl group having 1-4 carbon atoms or a trifluoromethyl group; R4 is a hydrogen atom or a lower alkyl group having 1-4 carbon atoms: R5 is a group represented by the general formula COOR6 (where R6 is a hydrogen atom or a lower alkyl group having 1-4 carbon atoms) or a group represented by the formula SO3H; and n is an integer of 1-4) or the general formula: 3 {where R7 is a lower alkyl group having 1-4 carbon atoms; R8 is a hydrogen atom or a lower alkyl group having 1-4 carbon atoms; R9 is a group represented by the general formula COOR10 (where R10 is a hydrogen atom or a lower alkyl group having 1-4 carbon atoms) or a group represented by the formula SO3H; and m is an integer of 1-4], or the general formula: 4 [where R11 is a hydrogen atom or a lower alkyl group having 1-4 carbon atoms; R12 is a hydrogen atom or a lower alkyl group having 1-4 carbon atoms; R13 is a group represent by the general formula COOR14 (where R14 is a hydrogen atom or a lower alkyl group having 1-4 carbon atoms) or a group represented by the formula SO3H; and l is an integer of 1 4], or the general formula: 5 [where R15 is a hydrogen atom or a lower alkyl group having 1-4 carbon atoms; R16 is a hydrogen atom or a lower alkyl group having 1-4 carbon atoms; and k is an integer of 2 or 3]}. All compounds represented by the general formula (II) 5 are novel except in the case where k is 2.

Dependencies are inferred from the claim text.