Pyrimidinonesulfamoylureas`

A compound of the general formula (I)

• 25
• where the radicals have the following meaning:
• T=CO2H, a radical hydrolyzable to CO2H or a radical isosteric to CO2H,
• X═(CRx1Rx2)a-(Gx)e-(CRx3Rx4)b-Wx—(CRx5Rx6)c—(Yx)f—(CRx7Rx8)d—where
• a, b, c, d independently of one another are 0, 1, 2 or 3,
• e, f independently of one another are 0 or 1,
• the sum of a, b, c, d, e and f is ≦10,
• Rx1, Rx2, Rx3, Rx4, Rx5, Rx6, Rx7, Rx8 independently of one another are hydrogen, halogen, a hydroxyl group, a branched or unbranched, optionally substituted C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or alkylenecycloalkyl radical, a radical —(CH2)r—(Yx)y—Rx9, an optionally substituted C3-C7-cycloalkyl, aryl, arylalkyl, hetaryl or hetarylalkyl radical, or independently of one another in each case two radicals Rx1 and Rx2 or Rx3 and Rx4 or Rx5 and Rx6 or Rx7 and Rx8 together are a 3- to 7-membered, optionally substituted, saturated or unsaturated carbo- or heterocycle, which can contain up to three heteroatoms from the group consisting of O, N and S,
• Rx9 is hydrogen, a hydroxyl group, CN, halogen, a branched or unbranched, optionally substituted C1-C6-alkyl, aryl or alkylenearyl radical, a primary or optionally secondary or tertiary substituted amino radical, a C2-C6-alkynyl or C2-C6-alkenyl radical optionally substituted by C1-C4-alkyl or aryl, a C5-C12-bicycloalkyl or C8-C20-tricycloalkyl radical, or a 3- to 6-membered, saturated or unsaturated heterocycle substituted by up to three identical or different radicals, which can contain up to three different or identical heteroatoms O, N, S, or a C3-C7-cycloalkyl, aryl or heteroaryl radical, where two radicals together can be a fused, saturated, unsaturated or aromatic carbocycle or heterocycle which can contain up to three different or identical heteroatoms O, N, S, and the cycle can be optionally substituted or a further, optionally substituted, saturated, unsaturated or aromatic cycle can be fused to this cycle,
• r=0-4
• Gx and Yx independently of one another are CO, CO—NRx10, NRx10CO, S, SO, SO2, SO2NRx10, NRx10SO2, CS, CS—NRx10, NRx10—CS, CS—O, O—CS, CO—O, O—CO, O, ethynyl, CRx11—O—CRx12, C(═CRx11Rx12) CRx11═CRx12, CRx11 (ORx13)—CRx12, CRx11—CRx12(ORx13)—,
• Rx10 is hydrogen, a branched or unbranched, optionally substituted C1-C6-alkyl, alkylenearyl, alkylenealkynyl, hetaryl or alkylenehetaryl radical, an optionally substituted C3-C7-cycloalkyl radical, CO—Rx14, COORx14, SO2—Rx14,
• Rx11, Rx12 independently of one another are hydrogen, a hydroxyl group, a branched or unbranched, optionally substituted C1-C6-alkyl, C1-C4-alkoxy, C2-C6-alkenyl, C2-C6-alkynyl or alkylenecycloalkyl radical or an optionally substituted C3-C7-cycloalkyl, aryl, arylalkyl, hetaryl or hetarylalkyl radical,
• R13 is hydrogen, a branched or unbranched, optionally substituted C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or alkylenecycloalkyl radical or an optionally substituted C3-C7-cycloalkyl, aryl, arylalkyl, hetaryl or hetarylalkyl radical,
• Rx14 is hydrogen, a hydroxyl group, a branched or unbranched, optionally substituted C1-C6-alkyl, aryl, heterocyclyl, heteroaryl, C3-7-cycloalkyl, alkylenecycloalkyl, alkylenearyl, alkyleneheterocyclyl, alkyleneheteroaryl, C2-6-alkenyl, C2-6-alkynyl, C1-4-alkoxy-C1-5-alkyl radical, where 1-2 atoms in saturated carbocyclic radicals can also be replaced by heteroatoms, preferably N, O, or S, and up to 2 double bonds can be contained.
• y=0, 1
• Wx:
• is —(CRw4Rw5)w—N Rw1SO2NRw2 Rw3
• where w=0-3
• Rw1 is hydrogen, a branched or unbranched, optionally substituted C1-C6-alkyl, C1-C6-alkoxyalkyl, alkylenearyl, alkylenealkynyl, hetaryl, CO—C1-C6-alkyl, CO—O—C1-C6-alkyl or SO2—C1-C6-alkyl radical or an optionally substituted C3-C7-cycloalkyl, CO—O-alkylenearyl, CO-alkylenearyl, CO-aryl, SO2-aryl, CO-hetaryl or SO2-alkylenearyl radical,
• Rw2, Rw3 independently of one another are hydrogen, a hydroxyl group, a branched or unbranched, optionally substituted C1-C8-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or alkylenecycloalkyl radical, an optionally substituted C3-C8-cycloalkyl, aryl, arylalkyl, hetaryl or hetarylalkyl radical, or independently of one another both radicals Rw2 and Rw3 together are a 3- to 7-membered, optionally substituted, saturated or unsaturated carbo- or heterocycle, which can contain up to three heteroatoms from the group consisting of O, N and S,
• Rw4, Rw5 independently of one another are C1-8-alkyl, halogen, OH, C1-8-alkoxy,
• R1, R2 independently of one another are hydrogen, halogen, CF3, CN, NO2, branched or unbranched C1-8-alkyl, C3-7-cycloalkyl, alkylcycloalkyl, where in each case 1-2 atoms in the cycloalkyl moiety can be replaced by N, O or S and up to 2 double bonds can be contained, aryl, alkylenearyl, hetaryl, alkylenehetaryl, C2-6-alkenyl, C3-6-alkynyl, C0-4-alkyl-OR3, C0-4-alkyl-SR3, SO—R3, SO2—R3, C0-4(CO)OR3, O(CO)R3, O(CO)NR4R5, C0-4-alkyl-SO2NR4R5, C0-4-(CO)NR4R5, C0-4-alkyl-NR4R5, CO—R3,
• or R1 and R2 together are a 3- to 9-membered optionally substituted cyclic or polycyclic system, which can contain 0-4 heteroatoms from the group consisting of O, N and S,
• R3 is H, or C1-8-alkyl, aryl, heterocyclyl, heteroaryl, C3-7-cycloalkyl, alkylenecycloalkyl, alkylenearyl, alkyleneheterocyclyl, alkyleneheteroaryl, C2-6-alkenyl, C2-6-alkynyl, C1-4-alkoxy-C1-5-alkylene, mono- or bisalkylaminoalkylene, acylaminoalkylene, each of which is branched or straight-chain and optionally substituted by halogen, OH, alkoxy, CN, COOH, COOC1-4-alkyl, where in saturated carbocyclic radicals 1-2 atoms can also be replaced by heteroatoms, preferably N, O, or S, and up to 2 double bonds can be contained,
• R4, R5 are H, C1-8-alkyl, aryl, heterocyclyl, heteroaryl, C3-7-cycloalkyl, alkylenecycloalkyl, alkylenearyl, alkyleneheterocyclyl, alkyleneheteroaryl, C2-6-alkenyl, C2-6-alkynyl, C1-4-alkoxy-C1-5-alkylene, mono- and bisalkylaminoalkylene, acylaminoalkylene, each of which is branched or straight-chain and optionally substituted by halogen, OH, alkoxy, CN, COOH, COOC1-4-alkyl, where in saturated carbocyclic radicals 1-2 atoms can also be replaced by heteroatoms, preferably N, O, or S, and up to 2 double bonds can be contained,
• A is a structural element selected from the group consisting of:
• a 4- to 8-membered monocyclic saturated, unsaturated or aromatic hydrocarbon, which can contain up to 4 heteroatoms, selected from the group consisting of O, N and S, where in each case independently of one another the ring nitrogen optionally contained or the carbons can be substituted,
• with the proviso that at least one heteroatom, selected from the group consisting of O, N and S, is contained in the structural element A, or
• a 9- to 14-membered polycyclic saturated, unsaturated or aromatic hydrocarbon, which can contain up to 6 heteroatoms, selected from the group consisting of N, O and S, where in each case independently of one another the ring nitrogen optionally contained or the carbons can be substituted,
• with the proviso that at least one heteroatom, selected from the group consisting of O, N and S, is contained in the structural element A,
• a radical
• 26
• where
• ZA1 is oxygen, sulfur or optionally substituted nitrogen, and
• ZA2 is optionally substituted nitrogen, oxygen or sulfur,
• or a radical
• 27
• where
• RA18, RA19
• independently of one another are hydrogen, a branched or unbranched, optionally substituted C1-C8-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C5-alkylene-C1-C4-alkoxy, mono- or bisalkylaminoalkylene or acylaminoalkylene radical or an optionally substituted aryl, heterocycloalkyl, heterocycloalkenyl, hetaryl, C3-C7-cycloalkyl, C1-C4-alkylene-C3-C7-cycloalkyl, arylalkyl, C1-C4-alkyleneheterocycloalkyl, C1-C4-alkyleneheterocycloalkenyl or hetarylalkyl radical, or a radical —SO2—R4, —CO—OR4, —CO—NR4R4 or —CO—R4,
• E is a spacer between A and the structural element pyrimidinone having 3-12 bonds.