Crystalline forms of 1S- [1alpha (2S*,3R*), 9alpha] 6, 10-dioxo-N- (2-ethoxy-5-oxo-tetrahydro-3- furanyl) -9[ [ (1-isoquinolyl) carbonyl] amino] octahydro-6H-piridazino [1,2-A] [1,2] diazepin-1-carboxamide
AssigneeAventis Pharma S.A.
InventorsJean-Yves Godard, Valerie Rognon
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Abstract
Two new crystalline forms of 1S-[1alpha(2S*,3R*),9alpha]6,10-dioxo-N-(2-ethoxy-5-oxo-tetrahydro-3-furanyl)-9[[(1-isoquinolyl)carbonyl]amino]octahydro-6H-pyridazino[1,2-a][1,2]diazepin-1-carboxamide (anhydrous or hydrated), their preparation process and the pharmaceutical compositions containing them.
Claims16
1) Crystalline form of anhydrous 1S-[1alpha(2S*,3R*),9alpha]6,10-dioxo-N-(2-ethoxy-5-oxo-tetrahydro-3-furanyl)-9[[(1-isoquinolyl)carbonyl]amino]octahydro-6H-piridazino[1,2-a][1,2]diazepin-1-carboxamide (form A).
5) Crystalline form of hydrated 1S-[1alpha(2S*,3R*),9alpha]6,10-dioxo-N-(2-ethoxy-5-oxo-tetrahydro-3-furanyl)-9[[(1-isoquinolyl)carbonyl]amino]octahydro-6H-piridazino[1,2-a][1,2]diazepin-1-carboxamide (Form B).
Dependencies are inferred from the claim text.