New compounds, their preparation and use

A compound of formula (I)

• 17
• wherein ring A and ring B, fused to the ring containing X and T, independently of each other represents a 5-6 membered cyclic ring, optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro, cyano, formyl, or C1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, C1-12-alkoxy, aryloxy, arylalkyl, arylalkoxy, heteroarylalkyl, heteroaryloxy, heteroarylalkoxy, acyl, acyloxy, hydroxyC1-12-alkyl, amino, acylamino, C1-12-alkyl-amino, arylamino, arylalkylamino, amino-C1-12-alkyl, C1-12-alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, C1-12-alkoxyC1-12-alkyl, aryloxyC1-12-alkyl, arylalkoxyC1-12-alkyl, C1-12-alkylthio, thioC1-12-alkyl, C1-12-alkoxycarbonylamino, aryloxycarbonylamino, arylalkoxycarbonylamino, bicycloalkyl, (C3-6-cycloalkyl)C1-6-alkyl, C1-6-dialkylamino, C1-6-alkylsulfonyl, C1-6-monoalkylaminosulfonyl, C1-6-dialkylaminosulfonyl, arylthio, arylsulfonyl, C1-6-monoalkylaminocarbonyl, C1-6-dialkylaminocarbonyl, —COR6 or —SO2R7, wherein R6 and R7 independently of each other are selected from hydroxy, halogen, perhalomethyl, C1-6-alkoxy or amino optionally substituted with one or more C1-6-alkyl or perhalomethyl;
• or aryl, wherein the aryl optionally can be substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano;
• or heteroaryl, wherein the heteroaryl optionally can be substituted with halogen, amino hydroxy, C1-6-alkyl or C1-6-alkoxy;
• or heterocyclyl, wherein the heterocyclyl optionally can be substituted with halogen, amino, hydroxy, C1-6-alkyl or C1-6-alkoxy;
• X is a valence bond, —(CHR8)—, —(CHR8)—CH2—, —CH═CH—, —O—(CHR8)—, —S—(CHR8)—, —(NR8)—CH2—, —(CHR8)—CH═CH—, —(CHR8)—CH2—CH2—, —(C═O)—, —O—CH2—O—, —(NR8)—S(O2)—, —CH═(CR8)—, —(CO)—(CHR8)—, —CH2—(SO)—, —(SO)—, —(SO2)—, —CH2—(SO2)—, —CH2—O—CH2—, wherein R8 is hydrogen, halogen, hydroxy, nitro, cyano, formyl, C1-12-alkyl, C1-12-alkoxy, aryl, aryloxy, arylalkyl, arylalkoxy, heterocyclyl, heteroaryl, heteroarylalkyl, heteroaryloxy, heteroarylalkoxy, acyl, acyloxy, hydroxyalkyl, amino, acylamino, C1-12-alkyl-amino, arylamino, arylalkylamino, aminoC1-12-alkyl, C1-12-alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, C1-12-alkoxyC1-12-alkyl, aryloxyC1-12-alkyl, arylalkoxyC1-12-alkyl, C1-12-alkylthio, thioC1-12-alkyl, C1-12-alkoxycarbonylamino, aryloxycarbonylamino, arylalkoxycarbonylamino, —COR9 or —SO2R10, wherein R9 and R10 independently of each other are selected from hydroxy, halogen, C1-6-alkoxy, amino optionally substituted with one or more C1-6-alkyl, perhalomethyl or aryl;
• T is N or CR14, wherein R14 is hydrogen, C1-12-alkoxy, C1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, aryl or arylalkyl;
• Y is C, O, S, CO, SO, SO2 or NR11, wherein R11 is hydrogen, C1-6-alkyl;
• k is 1 or 2;
• represents a single or a double bond;
• Ar is arylene, heteroarylene, or a divalent heterocyclic group each of which can optionally be substituted with one or more halogen,C1-6-alkyl, amino, hydroxy, C1-6-alkoxy or aryl;
• R1 is hydrogen, hydroxy, halogen, C1-12-alkoxy, C1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl or arylalkyl;
• optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano;
• R2 is hydrogen, hydroxy, halogen, C1-12-alkoxy, C1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl or arylalkyl;
• optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano;
• or R2 forms a bond together with R3;
• R3 is hydrogen, hydroxy, halogen, C1-12-alkoxy, C1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, acyl or arylalkyl;
• optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano;
• or R3 forms a bond together with R2;
• R4 is hydrogen, C1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, aryl, arylalkyl, heterocyclyl, heteroaryl or heteroarylalkyl groups;
• optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano;
• R5 is hydrogen, C1-12-alkyl, C4-12-alkenynyl, C2-12-alkenyl, C2-12-alkynyl, aryl, arylalkyl, heterocyclyl, heteroaryl or heteroarylalkyl groups;
• optionally substituted with one or more halogen, perhalomethyl, hydroxy, nitro or cyano;
• Z is oxygen or NR12, wherein R12 represents hydrogen C1-12-alkyl, aryl, hydroxyC1-12-alkyl or arylalkyl groups or when Z is NR12, R4 and R12 may form a 5 or 6 membered nitrogen containing ring, optionally substituted with one or more C1-6-alkyl;
• Q is oxygen or NR13, wherein R13 represents hydrogen C1-12-alkyl, aryl, hydroxyC1-12-alkyl or arylalkyl groups or when Q is NR13, R5 and R13 may form a 5 or 6 membered nitrogen containing ring, optionally substituted with one or more C1-6-alkyl;
• n is an integer ranging from 0 to 3;
• m is an integer ranging from 0 to 1;
• p is an integer ranging from 0 to 1;
• or a salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, including a racemic mixture, or any tautomeric forms.