Compounds

A compound of formula I or a pharmaceutically acceptable salt or solvate thereof

• 112
• For A, either:
• (i) A represents a single bond;
• optionally substituted C1 to C8 alkylene;
• a C2 to C12 group having at least one alkene double bond;
• a 3- to 8-membered heterocyctic ring containing from 1 to 4 heteroatoms independently selected from O, N and S or —R—Ar—R′—, where R and R′ are independently selected from a bond, optionally substituted C1 to C8 alkylene and a C2 to C12 group having at least one alkene double bond;
• and Ar represents optionally substituted aryl;
• or
• (ii) the structure N—A(—R4) represents a 3- to 8-membered heterocyclic ring optionally containing from 1 to 3 further heteroatoms independently selected from O, N and S, N—A(—R4) being optionally substituted;
• B represents a bond or optionally substituted C1 to C5 alkylene;
• C represents a mono- or bi-cyclic aromatic ring structure optionally having at least one substituent selected from CN;
• NR5R6;
• an optionally substituted C1 to C8 alkyl;
• optionally substituted C1 to C8 alkoxy;
• halogen;
• D represents hydrogen;
• optionally substituted C1 to C8 alkyl;
• or (CH2)b—R, wherein R represents C3 to C8 cycloalkyl;
• E is selected from an optionally substituted 3- to 8-membered heterocyclic ring containing from 1 to 4 heteroatoms independently selected from O, N and S;
• II;
• III;
• IV;
• V;
• VI and VII
• 113
• wherein het represents an optionally substituted 3- to 8-membered heterocyclic ring containing from 1 to 4 heteroatoms independently selected from O, N and S;
• F is optionally substituted and represents phenyl or a 3- to 8-membered heterocyclic ring containing from 1 to 4 heteroatoms independently selected from O, N and S;
• For X and Y, either:
• (iii) X represents N and Y represents CN or H;
• or X represents CH and Y represents NO2;
• or
• (iv) X—Y represents O;
• For R1 and R2, either:
• (v) R1 and R2 are independently selected from hydrogen and optionally substituted C1 to C8 alkyl;
• or
• (vi) R1 and R2 together represent carbonyl;
• or
• (vii)
• 114
• represents an optionally substituted 3- to 8-membered heterocyclic ring containing from 1 to 3 further heteroatoms independently selected from O, N and S, and R2 meets the definition in option (v);
• R3 meets the definition in option (vii) or represents hydrogen or optionally substituted C1 to C8 alkyl;
• R4 meets the definition in option (ii) or represents hydrogen or optionally substituted C1 to C8 alkyl;
• R5 and R6 are independently selected from H;
• optionally substituted C1 to C8 alkyl and optionally substituted aryl;
• For R7 and R7a, either:
• (viii) R7 and R7a are independently selected from H or optionally substituted C1 to C8 alkyl;
• or
• (ix)
• 115
• represents an optionally substituted 3 to 7-membered cycloalkyl ring;
• For R8 and R9, either:
• (x) R8 is selected from H;
• optionally substituted C1 to C8 alkyl;
• optionally substituted aryl;
• —R—Ar, where R represents C1 to C8 alkylene and Ar represents optionally substituted aryl;
• and an optionally substituted 3- to 8-membered heterocyclic ring optionally containing from 1 to 3 further heteroatoms independently selected from O, N and S;
• and
• R9 is selected from H;
• optionally substituted C1 to C8 alkyl and optionally substituted aryl;
• or
• (xi) wherein E represents structure II or III, NR8(—R9) represents an optionally substituted 3- to 8-membered heterocyclic ring optionally containing from 1 to 3 further heteroatoms independently selected from O, N and S;
• or
• (xii)wherein E represents structure VI,
• 116
• represents an optionally substituted 3- to 8-membered heterocyclic ring optionally containing from 1 to 4 heteroatoms independently selected from O, N and S;
• b represents zero or an integer from 1 to 6.