Diagnosis and management of infection caused by Chlamydia
AssigneeVanderbilt University
InventorsWilliam M. Mitchell, Charles W. Stratton
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Abstract
The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae. The invention is based, in part, upon the discovery that a combination of agents directed toward the various stages of the chlamydial life cycle is effective in substantially reducing infection. Products comprising combination of antichlamydial agents, novel compositions and pharmaceutical packs are also described.
Claims43
A method of treating Alzheimer's disease in a human patient in need thereof, said method comprising the step of administering to the patient at least two agents, each of which is effective against a different phase of chlamydial life cycle, until the biological material is negative for Chlamydia according to a test that detects elementary body phase Chlamydia, replicating phase Chlamydia, and cryptic phase Chlamydia, thereby treating said Alzheimer's disease.
A method of treating Alzheimer's disease in a mammal, said method comprising administering to said mammal an antichlamydial agent, wherein said antichlamydial agent inhibits infection of cells or inhibits growth or replication of C. pneumoniae in said mammal, thereby treating said Alzheimer's disease.
A method of treating Alzheimer's disease in a human patient, said method comprising administering to said patient an antichlamydial agent and an anti- inflammatory agent, wherein said antchlamydial agent inhibits infection of cells or inhibits growth or replication of C. pneumoniae in said human, thereby treating said Alzheimer's disease.
Dependencies are inferred from the claim text.