8Beta-substituted 11beta-aryl-estra-1,3,5,(10)-triene derivatives

Compounds of general formula I

• 12
• in which
• R2 means hydrogen, halogen (F, Cl, Br, I);
• a radical R18 or R18O, whereby R18 means hydrogen, an alkyl radical or alkanoyl radical (straight-chain or branched-chain, saturated or unsaturated with up to 6 carbon atoms and up to 2 multiple bonds), a benzoyl radical, a trifluoromethyl group;
• a radical R19SO2O, in which R19 means an R20R21N group, in which R20 and R21, independently of one another, mean a hydrogen, a C1-C5-alkyl radical, a group C(O)R22, in which R22 means a hydrocarbon radical (optionally substituted, straight-chain or branched-chain, saturated or unsaturated in up to three places, partially or completely halogenated) with up to 10 carbon atoms), an optionally substituted C3-C7-cycloalkyl radical, an optionally substituted C4-C15-cycloalkylalkyl radical or an optionally substituted aryl, heteroaryl or aralkyl radical, or, together with the N-atom, means a polymethylenimino radical with 4 to 6 C atoms or a morpholino radical;
• R3 means a radical R18O, R19SO2O or OC(O)R22, with R18, R19 and R22 in the meaning that is indicated under R2, and in addition R18 means an aryl, hetaryl or aralkyl radical;
• R6,R7 mean hydrogen;
• R6′ means hydrogen, a hydroxy group, a group R22 in the meaning that is indicated under R2;
• R7′ means hydrogen, halogen, a group R18O, R19SO2O, OC(O)R22, with R18, R19, and R22 in the meaning that is indicated under R2;
• R8 means an alkyl radical or alkenyl radical (both straight-chain or branched-chain, optionally partially or completely halogenated, with up to 5 carbon atoms), an ethinyl or prop-1-inyl radical;
• X means a direct bond, an oxygen or sulfur atom,
• n means an integer from 1 to 12, whereby the corresponding alkylene group can be interrupted by up to 3 O, S or N-methyl,
• Y means an amine —NR25R26, with R25 and R26 of the same or a different type, hydrogen, a hydrocarbon radical (optionally substituted, straight-chain or branched-chain, saturated or unsaturated in up to three places, optionally partially or completely halogenated) with up to 10 carbon atoms, an optionally substituted C3-C7-cycloalkyl radical, an optionally substituted C4-C15-cycloalkylalkyl radical or an optionally substituted aryl, heteroaryl or aralkyl radical or together with the nitrogen a heterocyclic compound (optionally with another heteoratom (O, S, N) that is optionally substituted with a C1-C4-alkyl radical),
• an amide CO—NR25R26 with R25, R26 of the same or a different type, hydrogen, a hydrocarbon radical (optionally substituted, straight-chain or branched-chain, saturated or unsaturated in up to three places, optionally partially or completely halogenated) with up to 10 carbon atoms, an optionally substituted C3-C7-cycloalkyl radical, an optionally substituted C4-C15-cycloalkylalkyl radical or an optionally substituted aryl, heteroaryl or aralkyl radical or together with the nitrogen a heterocyclic compound (optionally with another heteroatom (O, S, N), optionally substituted with a C1-C4-alkyl radical),
• a grouping —S(O)mR27 with m=0, 1 or 2, and R27 as a hydrocarbon radical (optionally substituted, straight-chain or branched-chain, saturated or unsaturated in up to three places, optionally partially or completely halogenated) with up to 10 carbon atoms, an optionally substituted C3-C7-cycloalkyl radical;
• an optionally substituted C4-C15-cycloalkylalkyl radical or an optionally substituted aryl, heteroaryl or aralkyl radical;
• R14 means hydrogen, an additional bond with R16;
• R15 means hydrogen, an additional bond with R14, R6;
• R16 means hydrogen, a bond with R15;
• R15′,R16′, independently of one another, mean hydrogen, halogen, a group R18O, R19SO2O or OC(O)R22, with R18, R19 and R22 in each case in the meaning that is indicated under R2;
• R17, R17′ each mean a hydrogen atom;
• a hydrogen atom and a halogen atom;
• a hydrogen atom and a benzyloxy group;
• a hydrogen atom and a group R19SO2—O—;
• a group R18 and a group —C(O)R22 or —O—C(O)R22;
• a group R18 —O— and a group R18—;
• a group R18 —O— and a group —O—C(O)R22, in each case with R18, R19 and R22 in the meaning that is indicated under R2;
• R17, R17′ together mean a group ═CR23R24, in which R23 and R24, independently of one another, represent a hydrogen atom and a halogen atom, or together represent an oxygen atom, as well as their pharmacologically compatible salts with acids in the case of the presence of a basic nitrogen atom in the compound of general formula I.