Antiviral formulations comprising propylene glycol and an isopropyl alkanoic acid ester
AssigneeMedivir AB
InventorGunilla Lekare
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Abstract
A topical composition comprising an antiinflammatory glucocorticoid and a nucleoside analogue antiviral agent in a pharmaceutical carrier characterized in that the carrier comprises about 15 to about 25 weight % propylene glycol and about 10 to about 25 weight percent isopropyl C12-C22 alkanoic ester. The compositions have utility in the treatment or prophylaxis of herpesvirus infections and exhibit superior antiviral and therapeutic efficacy and an improved shelf life.
Claims28
A topical composition comprising an antiinflammatory glucocorticoid and a nucleoside analogue antiviral agent in a pharmaceutical oil in water or water in oil emulsion carrier wherein the carrier comprises about 15 to about 25 weight percent, relative to the total formulation weight, propylene glycol and about 10 to about 25 weight percent, relative to the total formulation weight, isopropyl C12-C22 alkonoic acid ester.
A method for the preparation of a topical composition comprising bringing an oil phase comprising 10-25 weight percent, relative to the total weight of the intended formulation, isopropyl C12-C22 alkanoic acid ester to a defined temperature, bringing an aqueous phase comprising 15-25 weight percent, relative to the total weight of the intended formulation, propylene glycol to the defined temperature, blending the two phases, adding effective amounts of an antiinflammatory glucocorticoid and a nucleoside analogue antiviral agent and homogenising the resultant blend.
Dependencies are inferred from the claim text.