Percutaneous absorption type steroid preparation for external use
OwnerYoshiko Furukawa, Ken-ichi Nakao +2inventors
InventorsYoshiko Furukawa, Ken-ichi Nakao, Takemasa Kokubo, Koichi Kanehira
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Abstract
A percutaneous absorption type steroid preparation for external use, wherein the preparation form of the preparation for external use is a patch that a pressure-sensitive adhesive layer containing a steroidal antiphlogistic is provided on a support, and the pressure-sensitive adhesive layer further contains a dissolution aid for the steroidal antiphlogistic and an accelerator for percutaneous absorption.
Claims14
(Amended) A percutaneous absorption type steroid preparation for external use comprising a steroidal antiphlogistic, wherein
- (1) the preparation form of the preparation for external use is a patch that a pressure-sensitive adhesive layer containing the steroidal antiphlogistic is provided on a support,
- (2) a pressure-sensitive adhesive component forming the pressure-sensitive adhesive layer is a rubber pressure-sensitive adhesive comprising a styrene-isoprene-styrene block copolymer as a base material, and
- (3) the pressure-sensitive adhesive layer contains, per 100 parts by weight of the pressure-sensitive adhesive,
- (A) 0.1 to 10 parts by weight of the steroidal antiphlogistic,
- (B) as a dissolution aid for the steroidal antiphlogistic, 0.6 to 12 parts by weight of crotamiton, ethanol, urea, a water-soluble organic amine, a propylene glycol fatty acid ester, 1-menthol, peppermint oil or a mixture of at least two thereof, and
- (C) as an accelerator for percutaneous absorption, 1 to 40 parts by weight of at least one selected from the group consisting of:
- (a) a glycerol alkyl ether, the alkyl group of which has 6 to 20 carbon atoms,
- (b) a polyoxyethylene alkyl ether, the number of repeating units (—O—CH2CH2—) of the polyoxyethylene chain of which is 1 to 9, and
- (c) a glycerol ester of a fatty acid having 6 to 18 carbon atoms.
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Dependencies are inferred from the claim text.