Treatment of prostate cancer

A method for the treatment or prophylaxis of prostate cancer or a related cancer or condition in a subject, said method comprising the administration to said subject of a symptom-ameliorating effective amount of a chemical agent obtainable from Euphorbia peplus or a derivative or chemical analog thereof which chemical agent is a diterpene selected from compounds of the ingenane, pepluane and jatrophane faiilies and X which chemical agent or derivative or chemical analog is represented by any one of the general formulae (I)-(V):

• 13
• wherein:
• n is 0-10 atoms selected from carbon, oxygen, nitrogen, sulfiur, phosphorus, silicon, boron, arsenic and selenium, wherein the ring defmed by said atoms is saturated or unsaturated, including epoxides and thioepoxides;
• A-T are independently selected fiom hydrogen, R1, R2, R3, F, Cl, Br, I, CN, OR1, SR1, NR1R2, N(=O)2, NR1OR2, ONR1R2, SOR1, SO2R1, SO3R1, SONR1R2, SO2NR1R2, SO3NR1R2, P(R1)3, P(=O)(R1)3, Si(R1)3, B(R1)2, (C=X)R3 or X(C=X)R3 where X is selected from sulfur, oxygen and nitrogen;
• R1 and R2 are each independently selected from C1-C20 alkyl (branched and/or straight chained), C1-C20 arylalkyl, C3-C8 cycloalkyl, C6-C14 aryl, C1-C14 heteroaryl, C1-C14 heterocycle, C2-C10 alkenyl (branched and/or straight chained), C2-C10 alkynyl (branched and/or straight chained), C1-C10 heteroarylalkyl, C1-C10 allcoxyalkyl, C1-C10 haloalkyl, dihaloalkyl, trihaloalkyl, haloalkoxy, C1-C10 [CN, OR1, SR1, NR1R2, N(=O)2, NR1OR2, ONR1R2, SOR1, SO2R1, SO3R1, SONR1R2, SO2NR1R2, SO3NR1R2, P(R1)3, P(=O)(R1)3, Si(R1)3, B(R1)2]alkyl;
• R3 is selected from R1, R2, CN, COR1, CO2R1, OR1, SR1, NR1R2, N(=O)2, NR1OR2, ONR1R2, SOR1, SO2R1, SO3R1, SONR1R2, SO2NR1R2, SO3NR1R2, P(R1)3, P(=O)(R1)3, Si(R1)3, B(R1)2;
• A connected to B (or C), D (or E), R (or Q), P (or O) or S (or T) is a selection of C1-C8 disubstituted (fused) saturated or unsaturated carbocyclic or heterocyclic rings further substituted by R3, (C=X)R3 and X(C=X)R3, including epoxides and thioepoxides;
• J connected to I (or H), G (or F), K (or L), M (or N) or S (or T) is a selection of C1-C8 disubstituted (fused) saturated and unsaturated carbocyclic or heterocyclic rings further substituted by R3, (C=X)R3 and X(C=X)R3, including epoxides and thioepoxides;
• D (or E) connected to B (or C) or G (or F);
• I (or H) connected to G (or F);
• P (or O) connected to R (or Q) or M (or N);
• K (or L) connected to N (or M) is a selection of C1-C8 disubstituted (fused) saturated or unsaturated carbocyclic or heterocyclic rings substituted by R3, (C=X)R3 and X(C=X)R3, including epoxides and thioepoxides;
• B and C, D and E, R and Q, P and O, I and H, G and F, K and L M and N or S and T are =X where X is selected from sulfur, oxygen, nitrogen, NR1R2, and =CriR2
• 14
• wherein:
• n is 0-10 atoms selected from carbon, oxygen, nitrogen, sulfur, phosphorus, silicon, boron, arsenic and selenium, wherein the ring defined by said atoms is saturated or unsaturated, including epoxides and thioepoxides;
• A′-T′ are independently selected from hydrogen, R4, R5, R6, F, Cl, Br, I, CN, COR4, CO2R4, OR4, SR4, NR4R5, CONR4R5, N(=O)2, NR4OR5, ONR4R5, SOR4, SO2R4, SO3R4, SONR4R5, SO2NR4R5, SO3NR4R5, P(R4)3, P(=O)(R4)3, Si(R4)3, B(R4)2, (C=X)R6 or X(C=X)R6 where X is selected from sulfur, oxygen and nitrogen;
• R4 and R5 are each, independently selected from C1-C20 alkyl (branched and/or straight chained), C1-C20 arylalkyl, C3-C8 cycloalkyl, C6-C14 aryl, C1-C14 heteroaryl, C1-C14 heterocycle, C2-C10 alkenyl (branched and/or straight chained), C2-C10 alkynyl (branched and/or straight chained), C1-C10 heteroarylalkyl, C1-C10 alkoxyalkyl, C1-C10 haloalkyl, dihaloalkyl, trihaloalkyl, haloalkoxy, C1-C10 [CN, OR4, SR4, NR4R5, N(=O)2, NR4RO5, ONR4R5, SOR4, SO2R4, SO3R4, SONR4R5, SO2NR4R5, SO3NR4R5, P(R4)3, P(=O)(R4)3, Si(R4)3, B(R4)2]alkyl;
• R6 is selected from R4, R5, CN, COR4, CO2R4, OR4, SR4, NR4R5, N(=O)2, NR4OR5, ONR4R5, SOR4, SO2R4, SO3R4, SONR4R5, SO2NR4R5, SO3NR5, P(R4)3, P(=O)(R4)3, Si(R4)3, B(R4)2;
• E′ and R′ or H′ and O′ is a C2-C8 saturated or unsaturated carbocyclic or heterocyclic ring system further substituted by R6, including epoxides and thioepoxides;
• O′ connected to M′ (or N′) or Q′ (or P′);
• R′ connected to Q′60 (or P′) or S′ (or T′);
• S′ (or T′) connected to A′ (or B′);
• A′ (or B′) connected to C′ (or D′);
• E′ connected to C′ (or D′) or F′ (or G′);
• H′ connected to I′;
• I′ connected to J′;
• J′ connected to K′;
• K′ connected to L′;
• L′ connected to M′ (or N′) are C1-C8 disubstituted (fused) saturated or unsaturated carbocyclic or heterocyclic ring systems further substituted by R6, (C=X)R6 and X(C=X)R6, including epoxides and thioepoxides;
• A′, B′and C′, D′and F′, G′and M′, N′and P′Q′and S′T′are =X where X is selected from sulfur, oxygen, nitrogen, NR4R5, (C=X)R6, X(CX)R6, and =CR7R8;
• R7 and R8 are each independently selected from R6, (C=X)R6 and X(C=X)R6
• 15
• wherein:
• n is 0-10 atoms selected from carbon, oxygen, nitrogen, sulfur, phosphorus, silicon, boron, arsenic and selenium, wherein the ring defined by said atoms is saturated or unsaturated, including epoxides and thioepoxides;
• A1-T1 are independently selected from hydrogen, R9, R10, R11, F, Cl, Br, I, CN, OR9, SR9, NR9R10, N(=O)2, NR9OR10, ONR9R10, SOR9, SO2R9, SO3R9, SONR9R10, SO2NR9R10, SO3NR9R10, P(R9)3, P(=O)(R9)3, Si(R9)3, B(R9)2, (C=X)R11 or X(C=X)R11, where X is selected from sulfiur, oxygen and nitrogen;
• R9 and R10 are each independently selected from C1-C20 alkyl (branched and straight chained), C1-C20 arylalkyl, C3-C8 cycloalkyl, C6-CI14 aryl, C1-C14 heteroaryl, C1-C14 heterocycle, C2-C10 alkenyl (branched and straight chained), C2-C10 alkynyl (branched and straight chained), C1-C10 heteroarylalkyl, C1-C10 alkoxyalkyl, C1-C10 haloalkyl, dihaloalkyl, trialoalkyl, haloalkoxy, C1-C10 [CN, OR9, SR9, NR9R10, N(=O)2, NR9OR10, ONR9R10, SOR9, SO2R9, SO3R9, SONR9R10, SO2NR9R10, SO3NR9R10, P(R9)3, P(=O)(R9)3, Si(R9)3, B(R9)2]alkyl;
• R11, is selected from R9, R10, CN, COR9, CO2R9, OR9, SR9, NR9R10, N(=O)2, NR9OR10, ONR9R10, SOR9, SO2R9, SO3R9, SONR9R10, SO2NR9R10, SO3NR9R10, P(R9)3, P(=O)(R9)3, Si(R9)3, B(R9)2;
• B1 and R1, E1 and Ö1 and Ë1 and M1 are selected from a C2-C8 saturated or unsaturated carbocyclic or heterocyclic ring system further substituted by R11, including epoxides and thioepoxides;
• A1 (or Ä1 connected to Á1 (or Ã1) or T1 (or S1);
• B1 connected to Á1 (or Ã1) or C1 (or D1). E1 connected to Ë1 or C1 (or D1);
• Ë1 connected to É1 (or F1);
• G1 (or H1) connected to É1 (or F1) or I1 (or J1);
• K1 (or L1) connected to I1 (or J1) or M1;
• M1 connected to O1 (or N1);
• Ö1 connected O1 (or N1) or P1 (or Q1);
• R1 connected P1 (or Q1) or S1 (or T1) are C1-C8 disubstituted (fused) saturated or unsaturated carbocyclic or heterocyclic ring systems further substituted by R11, (C=X)R11, and X(C=X)R11, including epoxides and thioepoxides;
• A1, Ä and Á, Ã and C1, D1 and F1, É and G1, H1 and I1, J1 and K1, L1 and N1, O1 and P1, Q1 and S1, T1 are =X where X is selected from sulfur, oxygen, nitrogen, NR9R10, including (C=X)R11, and X(C=X)R11, and =CR12R13;
• R12 and R13 are independently selected from R11, (C=X)R11, and X(C=X)R11,
• 16
• wherein:
• n is 0-10 atoms selected fiom carbon, oxygen, nitrogen, sulfur, phosphorus, silicon, boron, arsenic and selenium, wherein the ring defined by said atoms is saturated or unsaturated, including epoxides and thioepoxides;
• A2-X2 are independently selected from hydrogen, R14, R15, R16, F, Cl, Br, I, CN, OR14, SR14, NR14R15, N(=O)2, NR14OR15, ONR14R15, SOR14, SO2R14, SO3R14, SONR14R15, SO2NR14R15, SO3NR14R15, P(R14)3, P(=O)(R14)3, Si(R14)3, B(R14), (C=Y)R16 or Y(C=Y)R16 where Y is selected from sulfur, oxygen and nitrogen;
• R14 and R15 are each independently selected from C1-C20 alkyl (branched and/or straight chained), C1-C20 arylalkyl, C3-C8 cycloalkyl, C6-C14 aryl, C1-C14 heteroaryl, C1-C14 heterocycle C2-C10 alkenyl (branched and/or straight chained), C2-C10 allkynyl (branched and/or straight chained), C1-C10 heteroarylalkyl, C1-C10 alkoxyalkyl, C1-C10 haloalkyl, dihaloalkyl, trihaloalkyl, haloalkoxy, C1-C10 [CN, OR14, SR14, NR14R10 , N(=O)2, NR14OR15, ONR14R15, SOR14, SO2R14, SO3R14, SONR14R15, SO2NR14R15, SO3NR14R15, P(R14)3, P(=O)(R14)3, Si(R14)3, B(R14)2]alkyl;
• R16 is selected from R14, R15, CN, COR14, CO2R15, OR14, SR14, N14R15, N(=O)2, NR14OR15, ONR14R15, SOR14, S2R14, SO3R14, SONR14R15, SO2NR14R15, SO3NR14R15, P(R4)3, P(=O)(R14)3, Si(R14)3, B(R14)2;
• E2 and V2, and H2 and S2, and I2 and P2 are C2-C8 saturated or unsaturated carbocyclic or heterocyclic ring system further substituted by R16, including epoxides and thioepoxides;
• A2 (or B2) connected to C2 (or D2) or W2 (or X2);
• E2 connected to C2 (or D2) or F2 (or G2);
• H2 connected to F2 (or G2 or I2;
• I2 connected to J2 (or K2);
• L2 (or M2) connected to J2 (or K2) or N2 (or O2);
• R2 (or Q2 connected to P2 or S2;
• V2 connected to U2 (or T2) or W2 (or X2) are C1-C8 disubstituted (fused) saturated or unsaturated carbocyclic or heterocyclic ring systems further substituted by R16, (C=Y)R16 and Y(C=Y)R16, including epoxides and thioepoxides;
• A2, B2;
• C2, D2;
• F2, G2;
• J2, K2;
• L2, M2;
• N2, O2;
• O2, R2;
• U2, T2 and X2, W2 are =Y where Y is selected from sulfur, oxygen, nitrogen, NR14R15 and =CR17R18;
• R17 and R18 are independently selected from R16, (C=Y)R16 and Y(C=Y)R16
• 17
• wherein:
• n is 0-10 atoms selected from carbon, oxygen, nitrogen, sulfur, phosphorus, silicon, boron, arsenic and selenium, wherein the ring defined by said atoms is saturated or unsaturated, including epoxides and thioepoxides;
• A3-Z3 are independently selected from hydrogen, R19, R20, R21, F, Cl, Br, I, CN, OR19, SR19, NR19R20, N(=O)2, NR19OR20, ONR19R20, SOR19, SO2R19, SO3R19, SONR19R20, SO2NR19R20, SO3NR19R20, P(R19)3, P(=O)(R19)3, Si(R19)3, B(R19)2, (C=Ø)R21 or Ø (C=Ø)R21 where Ø is sulfur, oxygen and nitrogen;
• R19 and R20 are each independently selected from C1-C20 alkyl (branched and/or straight chained), C1-C20 arylalkyl, C3-C8 cycloalkyl, C6-C14 aryl, C1-C14 heteroaryl, C1-C14 heterocycle, C2-C10 alkenyl (branched and/or straight chained), C2-C10 alkynyl (branched and/or straight chained), C1-C10 heteroarylalkyl, C1-C10 allkoxyalkyl, C1-C10 haloalkyl, dihaloalkyl, trihaloalkyl, haloalkoxy, C1-C10 [CN, OR19, SR19, NR19R20, N(=O)2, NR,19OR20, ONR19R20, SOR19, SO2R19, SO3R19, SONR19R20, SO2NR19R20, SO3NR19R20, P(R19)3, P(=O)(R19)3, Si(R19)3, B(R19)2]alkyl;
• R21 is selected from R19, R20, CN, COR19, CO2R19, OR19, SR19, NR19R20, N(=O)2, NR19OR20, ONR19R20, SOR19, SO2R19, SO3R19, SONR19R20, SO2NR19R20, SO3NR19R20, P(R19)3, P(=O)(R19)3, Si(R19)3, B(R19)2;
• D3 connected to X3 is a C2-C8 saturated or unsaturated carbocyclic or heterocyclic ring system further substituted by R21, including epoxides and thioepoxides;
• A3 (or Ä3) connected to B3 (or C3) or Z3 (or Y3);
• D3 connected to B3 (or C3) or E3 (or F3);
• G3 (or H3) connected to E3 (or F3) or I3 (or J3);
• L3 (or K3) connected to I3 (or J3) or M3 (or N3);
• O3 (or Ö3) connected to N3 (or M3) or P3 (or Q3). S3 (or R3) connected to Q3 (or P3) or U3 (or T3). W3 (or V3) connected to U3 (or T3) or X3;
• X3 connected to Y3 (or Z3) are C1-C8 disubstituted (fused) saturated or unsaturated carbocyclic or heterocyclic ring systems further substituted by R21, (C=Ø)R21 and Ø (C=Ø)R21, including epoxides and thioepoxides;
• A3, A3;B3,C3;
• E3,F3;
• G3, H3;
• I3, J3;
• K3, L3;
• M3,N3;
• O3, {umlaut over (0)}3;
• Q3,P3, R3, U3, T3, W3, V3, and Z3,Y3 are =Ø where Ø is selected from sulfur, oxygen, nitrogen, NR19R20, and =CR22R23;
• and
• R22 and R23 are selected from R21, (C=Ø)R21 and Ø (C=Ø)R21;
• and which chemical agent or derivative or chemical analogis administered for a time and under conditions sufficient to ameliorate one or more symptoms associated with said prostate cancer or related cancer or condition.

A method for the immunopotentiation of a subject in the treatment or prophylaxis of prostate cancer or a related condition, said method comprising the administration to said subject of a symptom-ameliorating effective amount of a chemical agent obtainable from a plant of the Euphorbiaceae fanily or a derivative or chemical analog thereof which chenical agent is a diterpene selected from compounds of the ingenane, pepluane and jatrophane families and which chemical agent or derivative or chemical analog is represented by any one of the general formulae (I)-(V):-

• 19
• wherein:
• n is 0-10 atoms selected from carbon, oxygen, nitrogen, sulfur, phosphorus, silicon, boron, arsenic and selenium, wherein the ring defined by said atoms is saturated or unsaturated, including epoxides and thioepoxides;
• A-T are independently selected from hydrogen, R1, R2, R3, F, Cl, Br, I, CN, OR1, SR1, NR1R2, N(=O)2, NR1OR2, ONR1R2, SOR1, SO2R1, SO3R1, SONR1R2, SO2NR1R2, SO3NR1R2, P(R1)3, P(=O)(R1)3, Si(R1)3, B R1)2, (C=X)R3 or X(C=X)R3 where X is selected from sulfuir, oxygen and nitrogen;
• R1 and R2 are each independently selected from C1-C20 alkyl (branched and/or straight chained), C1-C20 arylalkyl, C3-C8 cycloalkyl, C6-C14 aryl, C1-C14 heteroaryl, C1-C14 heterocycle, C2-C10 alkenyl (branched and/or straight chained), C2-C10 alkynyl (branched andlor straight chained), C1-C10 heteroarylalkyl, C1-C10 alkoxyalkyl, C1-C10 haloalkyl, dihaloalkyl, trihaloallkyl, haloalkoxy, C1-C10 [CN, OR1, SR1, NR1R2, N(=O)2, NR1OR2, ONR1R2, SOR1, SO2R1, SO3R1, SONR1R2, SO2NR1R2, SO3NR1R2, P(R1)3, P(=O)(R1)3, Si(R1)3, B(R1)2]alkyl;
• R3 is selected from R1, R2, CN, COR1, CO2R1, OR1, SR1, NR1R2, N(=O)2, NR1OR2, ONR1R2, SOR1, SO2R1, SO3R1, SONR1R2, SO2NR1R2, SO3NR1R2, P(R1)3, P(=O)(R1)3, Si(R1)3, B(R1)2;
• A connected to B (or C), D (or E), R (or Q), P (or O) or S (or T) is a selection of C1-C8 disubstituted (fused) saturated or unsaturated carbocyclic or heterocyclic rings further substituted by R3, (C=X)R3 and X(C=X)R3, including epoxides and thioepoxides;
• J connected to I (or H), G (or F), K (or L), M (or N) or S (or T) is a selection of C1-C8 disubstituted (fused) saturated and unsaturated carbocyclic or heterocyclic rings further substituted by R3, (C=X)R3 and X(C=X)R3, including epoxides and thioepoxides;
• D (or E) connected to B (or C) or G (or F);
• I (or H) connected to G (or F);
• P (or O) connected to R (or Q) or M (or N);
• K (or L) connected to N (or M) is a selection of C1-C8 disubstituted (fused) saturated or unsaturated carbocyclic or heterocyclic rings substituted by R3, (C=X)R3 and X(C=X)R3, including epoxides and thioepoxides;
• B and C, D and E, R and Q, P and O, I and H, G and F, K and L, M and N or S and T are =X where X is selected from sulfur, oxygen, nitrogen, NR1R2, and =Cr1R2
• 20
• wherein:
• n is 0-10 atoms selected from carbon, oxygen, nitrogen, sulfiu, phosphorus, silicon, boron, arsenlic and selenium, wherein the ring defined by said atoms is saturated or unsaturated, including epoxides and thioepoxides;
• A′-T′ are independently selected from hydrogen, R4, R5, R6, F, Cl, Br, I, CN, COR4, CO2R4, OR4, SR4, NR4R5, CONR4R5, N(=O)2, NR4OR5, ONR4R5, SOR4, SO2R4, SO3R4, SONR4R5, SO2NR4R5, SO3NR4R5, P(R4)3, P(=O)(R4)3, Si(R4)3, B(R4)2, (C=X)R6 or X(C=X)R6 where X is selected from sulfur, oxygen and nitrogen;
• R4 and R5 are each, independently selected from C1-C20 alkyl (branched and/or straight chained), C1-C20 arylalkyl, C3-C8 cycloalkyl, C6-C14 aryl, C1-C14 heteroaryl, C1-C14 heterocycle, C2-C10 alkenyl (branched and/or straight chained), C2-C10 alkynyl (branched and/or straight chained), C1-C10 heteroarylalkyl, C1-C10 alkoxyalkyl, C1-C10 haloalkyl, dihaloalkyl, trihaloalkyl, haloalkoxy, C1-C10 [CN, OR4, SR4, NR4R5, N(=O)2, NR4RO5, ONR4R5, SOR4, SO2R4, SO3R4, SONR4R5, SO2NR4R5, SO3NR4R5, P(R4)3, P(=O)(R4)3, Si(R4)3, B(R4)2]alkyl;
• R6 is selected from R4, R5, CN, COR4, CO2R4, OR4, SR4, NR4R5, N(=O)2, NR4OR5, ONR4R5, SOR4, SO2R4, SO3R4, SONR4R5, SO2NR4R5, SO3NR5, P(R4)3, P(=O)(R4)3, Si(R4)3, B(R4)2;
• E′ and R′ or H′ and O′ is a C2-C8 saturated or unsaturated carbocyclic or heterocyclic ring system further substituted by R6, including epoxides and thioepoxides;
• O′ connected to M′ (or N′) or Q′ (or P′);
• R′ connected to Q′60 (or P′) or S′ (or T′);
• S′ (or T′) connected to A′ (or B′);
• A′ (or B′) connected to C′ (or D′);
• E′ connected to C′ (or D′) or F′ (or G′);
• H′ connected to I′;
• I′ connected to J′;
• J′ connected to K′;
• K′ connected to L′;
• L′ connected to M′ (or N′) are C1-C8 disubstituted (fused) saturated or unsaturated carbocyclic or heterocyclic ring systems further substituted by R6, (C=X)R6 and X(C=X)R6, including epoxides and thioepoxides;
• A′, B′and C′, D′and F′, G′and M′, N′and P′Q′and S′T′are =X where X is selected from sulfur, oxygen, nitrogen, NR4R5, (C=X)R6, X(CX)R6, and =CR7R8;
• R7 and R8 are each independently selected from R6, (C=X)R6 and X(C=X)R6
• 21
• wherein:
• n is 0-10 atoms selected from carbon, oxygen, nitrogen, sulfur, phosphorus, silicon, boron, arsenic and selenium, wherein the ring defined by said atoms is saturated or unsaturated, including epoxides and thioepoxides;
• A1-T1 are independently selected from hydrogen, R9, R10, R11, F, Cl, Br, I, CN, OR9, SR9, NR9R10, N(=O)2, NR9OR10, ONR9R10, SOR9, SO2R9, SO3R9, SONR9R10, SO2NR9R10, SO3NR9R10, P(R9)3, P(=O)(R9)3, Si(R9)3, B(R9)2, (C=X)R11 or X(C=X)R11, where X is selected from sulfiur, oxygen and nitrogen;
• R9 and R10 are each independently selected from C1-C20 alkyl (branched and straight chained), C1-C20 arylalkyl, C3-C8 cycloalkyl, C6-CI14 aryl, C1-C14 heteroaryl, C1-C14 heterocycle, C2-C10 alkenyl (branched and straight chained), C2-C10 alkynyl (branched and straight chained), C1-C10 heteroarylalkyl, C1-C10 alkoxyalkyl, C1-C10 haloalkyl, dihaloalkyl, trialoalkyl, haloalkoxy, C1-C10 [CN, OR9, SR9, NR9R10, N(=O)2, NR9OR10, ONR9R10, SOR9, SO2R9, SO3R9, SONR9R10, SO2NR9R10, SO3NR9R10, P(R9)3, P(=O)(R9)3, Si(R9)3, B(R9)2]alkyl;
• R11, is selected from R9, R10, CN, COR9, CO2R9, OR9, SR9, NR9R10, N(=O)2, NR9OR10, ONR9R10, SOR9, SO2R9, SO3R9, SONR9R10, SO2NR9R10, SO3NR9R10, P(R9)3, P(=O)(R9)3, Si(R9)3, B(R9)2;
• B1 and R1, E1 and Ö1 and Ë1 and M1 are selected from a C2-C8 saturated or unsaturated carbocyclic or heterocyclic ring system further substituted by R11, including epoxides and thioepoxides;
• A1 (or Ä1 connected to Á1 (or Ã1) or T1 (or S1);
• B1 connected to Á1 (or Ã1) or C1 (or D1). E1 connected to Ë1 or C1 (or D1);
• Ë1 connected to É1 (or F1);
• G1 (or H1) connected to É1 (or F1) or I1 (or J1);
• K1 (or L1) connected to I1 (or J1) or M1;
• M1 connected to O1 (or N1);
• Ö1 connected O1 (or N1) or P1 (or Q1);
• R1 connected P1 (or Q1) or S1 (or T1) are C1-C8 disubstituted (fused) saturated or unsaturated carbocyclic or heterocyclic ring systems further substituted by R11, (C=X)R11, and X(C=X)R11, including epoxides and thioepoxides;
• A1, Ä and Á, Ã and C1, D1 and F1, É and G1, H1 and I1, J1 and K1, L1 and N1, O1 and P1, Q1 and S1, T1 are =X where X is selected from sulfur, oxygen, nitrogen, NR9R10, including (C=X)R11, and X(C=X)R11, and =CR12R13;
• R12 and R13 are independently selected from R11, (C=X)R11, and X(C=X)R11,
• 22
• wherein:
• n is 0-10 atoms selected from carbon, oxygen, nitrogen, sulfur, phosphorus, silicon, boron, arsenic and selenium, wherein the ring defined by said atoms is saturated or unsaturated, including epoxides and thioepoxides;
• A2-X2 are independently selected from hydrogen, R14, R15, R16, F, Cl, Br, I, CN, OR14, SR14, NR14R15, N(=O)2, NR14OR15, ONR14R15, SOR14, SO2R14, SO3R14, SONR14R15, SO2NR14R15, SO3NR14R15, P(R14)3, P(=O)(R14)3, Si(R14)3, B(R14), (C=Y)R16 or Y(C=Y)R16 where Y is selected from sulfur, oxygen and nitrogen;
• R14 and R15 are each independently selected from C1-C20 alkyl (branched and/or straight chained), C1-C20 arylalkyl, C3-C8 cycloalkyl, C6-C14 aryl, C1-C14 heteroaryl, C1-C14 heterocycle C2-C10 alkenyl (branched and/or straight chained), C2-C10 allkynyl (branched and/or straight chained), C1-C10 heteroarylalkyl, C1-C10 alkoxyalkyl, C1-C10 haloalkyl, dihaloalkyl, trihaloalkyl, haloalkoxy, C1-C10 [CN, OR14, SR14, NR14R10 , N(=O)2, NR14OR15, ONR14R15, SOR14, SO2R14, SO3R14, SONR14R15, SO2NR14R15, SO3NR14R15, P(R14)3, P(=O)(R14)3, Si(R14)3, B(R14)2]alkyl;
• R16 is selected from R14, R15, CN, COR14, CO2R15, OR14, SR14, N14R15, N(=O)2, NR14OR15, ONR14R15, SOR14, S2R14, SO3R14, SONR14R15, SO2NR14R15, SO3NR14R15, P(R4)3, P(=O)(R14)3, Si(R14)3, B(R14)2;
• E2 and V2, and H2 and S2, and I2 and P2 are C2-C8 saturated or unsaturated carbocyclic or heterocyclic ring system further substituted by R16, including epoxides and thioepoxides;
• A2 (or B2) connected to C2 (or D2) or W2 (or X2);
• E2 connected to C2 (or D2) or F2 (or G2);
• H2 connected to F2 (or G2 or I2;
• I2 connected to J2 (or K2);
• L2 (or M2) connected to J2 (or K2) or N2 (or O2);
• R2 (or Q2 connected to P2 or S2;
• V2 connected to U2 (or T2) or W2 (or X2) are C1-C8 disubstituted (fused) saturated or unsaturated carbocyclic or heterocyclic ring systems further substituted by R16, (C=Y)R16 and Y(C=Y)R16, including epoxides and thioepoxides;
• A2, B2;
• C2, D2;
• F2, G2;
• J2, K2;
• L2, M2;
• N2, O2;
• O2, R2;
• U2, T2 and X2, W2 are =Y where Y is selected from sulfur, oxygen, nitrogen, NR14R15 and =CR17R18;
• R17 and R18 are independently selected from R16, (C=Y)R16 and Y(C=Y)R16
• 23
• wherein:
• n is 0-10 atoms selected from carbon, oxygen, nitrogen, sulfur, phosphorus, silicon, boron, arsenic and selenium, wherein the ring defined by said atoms is saturated or unsaturated, including epoxides and thioepoxides;
• A3-Z3 are independently selected from hydrogen, R19, R20, R21, F, Cl, Br, I, CN, OR19, SR19, NR19R20, N(=O)2, NR19OR20, ONR19R20, SOR19, SO2R19, SO3R19, SONR19R20, SO2NR19R20, SO3NR19R20, P(R19)3, P(=O)(R19)3, Si(R19)3, B(R19)2, (C=Ø)R21 or Ø (C=Ø)R21 where Ø is sulfur, oxygen and nitrogen;
• R19 and R20 are each independently selected from C1-C20 alkyl (branched and/or straight chained), C1-C20 arylalkyl, C3-C8 cycloalkyl, C6-C14 aryl, C1-C14 heteroaryl, C1-C14 heterocycle, C2-C10 alkenyl (branched and/or straight chained), C2-C10 alkynyl (branched and/or straight chained), C1-C10 heteroarylalkyl, C1-C10 allkoxyalkyl, C1-C10 haloalkyl, dihaloalkyl, trihaloalkyl, haloalkoxy, C1-C10 [CN, OR19, SR19, NR19R20, N(=O)2, NR,19OR20, ONR19R20, SOR19, SO2R19, SO3R19, SONR19R20, SO2NR19R20, SO3NR19R20, P(R19)3, P(=O)(R19)3, Si(R19)3, B(R19)2]alkyl;
• R21 is selected from R19, R20, CN, COR19, CO2R19, OR19, SR19, NR19R20, N(=O)2, NR19OR20, ONR19R20, SOR19, SO2R19, SO3R19, SONR19R20, SO2NR19R20, SO3NR19R20, P(R19)3, P(=O)(R19)3, Si(R19)3, B(R19)2;
• D3 connected to X3 is a C2-C8 saturated or unsaturated carbocyclic or heterocyclic ring system further substituted by R21, including epoxides and thioepoxides;
• A3 (or Ä3) connected to B3 (or C3) or Z3 (or Y3);
• D3 connected to B3 (or C3) or E3 (or F3);
• G3 (or H3) connected to E3 (or F3) or I3 (or J3);
• L3 (or K3) connected to I3 (or J3) or M3 (or N3);
• O3 (or Ö3) connected to N3 (or M3) or P3 (or Q3). S3 (or R3) connected to Q3 (or P3) or U3 (or T3). W3 (or V3) connected to U3 (or T3) or X3;
• X3 connected to Y3 (or Z3) are C1-C8 disubstituted (fused) saturated or unsaturated carbocyclic or heterocyclic ring systems further substituted by R21, (C=Ø)R21 and Ø (C=Ø)R21, including epoxides and thioepoxides;
• A3, A3;B3,C3;
• E3,F3;
• G3, H3;
• I3, J3;
• K3, L3;
• M3,N3;
• O3, {umlaut over (0)}3;
• Q3,P3, R3, U3, T3, W3, V3, and Z3,Y3 are =Ø where Ø is selected from sulfur, oxygen, nitrogen, NR19R20, and =CR22R23;
• and
• R22 and R23 are selected from R21, (C=Ø)R21 and Ø (C=Ø)R21;
• and which chemical agent or derivative or chemical analogis administered for a time and under conditions sufficient to potentiate the immune system or components therein.