Antibacterial compound

A compound of the following formula (I), a pharmaceutically acceptable ester, ether or N-alkyl derivative thereof, or a pharmaceutically acceptable salt thereof:

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• wherein
• X1 represents an oxygen atom, a sulfur atom or a group of formula —N(R4)—, in which R4 is a hydrogen atom, a C1-C3 alkyl group, or R4, together with R1 and the nitrogen atom to which they are attached, forms a 3- to 7-membered cyclic amine which optionally has a ring oxygen or sulfur atom;
• X2 represents an oxygen atom, a sulfur atom or a group of formula —N(R5)—, in which R5 is a hydrogen atom, a C1-C3 alkyl group, or R5, together with R2 and the nitrogen atom to which they are attached, forms a 3- to 7-membered cyclic amine which optionally has a ring oxygen or sulfur atom);
• R1 and R2 are the same or different and each represents:
• (1) a hydrogen atom,
• (2) a C6-C10 aryl group which is unsubstituted or has one or more substituents of a Substituent Group A selected from the group consisting of a halogen atom;
• a hydroxyl group;
• an amino group, said amino group being unsubstituted or substituted with one or more C1-C6 alkyl groups;
• a nitro group;
• a cyano group;
• a carboxyl group;
• a C1-C4 alkoxycarbonyl group;
• a carbamoyl group;
• a C1-C10 alkylenedioxy group, a C7-C14 aralkyloxy group;
• a C1-C16 alkyl group, said alkyl group being unsubstituted or substituted with one or more halogen atoms;
• a C2- C16 alkenyl group;
• a C1-C16 alkoxy group, said alkoxy group being unsubstituted or substituted with one or more halogen atoms;
• a C1-C16 alkylthio group, said alkylthio group being unsubstituted or substituted with one or more halogen atoms;
• a C6-C10 arylazo group;
• and a heterocyclic group which has 1-4 ring nitrogen, sulfur or oxygen atoms,
• (3) a heterocyclic group which has 1-4 nitrogen, sulfur or oxygen atoms and which is unsubstituted or substituted by one or more substituents of a Substituent Group B selected from the group consisting of an oxo group;
• a thiooxo group;
• an imino group;
• a halogen atom;
• a hydroxyl group;
• an amino group, said amino group being unsubstituted or substituted with one or more C1-C16 alkyl groups;
• a nitro group;
• a cyano group;
• a carboxyl group;
• a C1- C4 alkoxycarbonyl group;
• a carbamoyl group;
• a C7-C14 aralkyloxy group;
• a C1-C16 alkyl group, said alkyl group being unsubstituted or substituted with one or more halogen atoms;
• a C1-C16 alkenyl group;
• a C1-C16 alkoxy group, said alkoxy group being unsubstituted or substituted with one or more halogen atoms;
• and a C1-C16 alkylthio group, said alkylthio group being unsubstituted or substituted with one or more halogen atoms;
• (4) a C1-C14 alkyl group which is substituted with one to three C6-C10 aryl groups which are the same or different and each is unsubstituted or have one or more substituents from the Substituent Group A;
• (5) a C1-C14 alkyl group which is substituted with one to three heterocyclic groups which are the same or different, have 1-4 nitrogen, sulfur or oxygen atoms and are unsubstituted or have one or more substituents from the Substituent Group B on the heterocyclic group;
• (6) a C1-C22 alkyl group which is unsubstituted or have one or more substituents of a Substituent Group C selected from the group consisting of a halogen atom, a hydroxyl group, an amino group, a nitro group, a cyano group, a carboxyl group, a C1-C4 alkoxycarbonyl group, a carbamoyl group, a C1-C16 alkoxy group, said alkoxy group being unsubstituted or substituted with one or more halogen atoms, and a C1-C16 alkylthio group, said alkylthio group being unsubstituted or substituted with one or more halogen atoms;
• (7) a C2-C22 alkenyl group which is unsubstituted or has one or more substituents, said one or more substituents are selected from those listed in (2) or (3) above or from said Substituent Group C;
• or
• (8) a group of formula (a)
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• in which n represents an integer from 1 to 20 and m represents 0 or 2;
• and
• R3 represents a hydrogen atom or a hydroxyl group;
• with the proviso that excluded are:
• a compound wherein X1 and X2 represent a group of formula —NH—, R1 represents a hydrogen atom or a group of the following formulae (II), (III), (IV) or (V), R2 is a hydrogen atom and R3 is a hydroxyl group, and
• a compound wherein X1 is an oxygen atom, X2 represents a group of formula —NH—, R1 represents a hydrogen atom or a methyl group, R2 is a hydrogen atom and R3 is a hydroxyl group
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