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US 2003/0171329 A1Published application
Stable compositions comprising tezacitabine
OwnerRichard E. Jones, Mike T. Li +3inventors
InventorsRichard E. Jones, Mike T. Li, Andy Trammel, Christine M. Harrison-Bowman, Kimberly R. Shirley
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Abstract
The present invention relates to tezacitabine ((E)-2′-fluoromethylene-2′-deoxycytidine) formulations which are stable for long periods of time. The present invention further relates to methods of formulating stable tezacitabine formulations.
Claims13
An aqueous composition comprising:
- a) water;
- b) tezacitabine;
- and
- c) a buffer which maintains the pH of the composition at about 7 or above.
1 more element
A method for enhancing the shelf life an aqueous solution of tezacitabine which said method comprises:
- a) preparing an aqueous solution of tezacitabine;
- and
- b) combining a sufficient amount of a buffer to the solution prepared in a) above to maintain the pH of the resulting solution at least 7 or above.
Dependencies are inferred from the claim text.