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US 2003/0171316 A1Published application
Use of prohibitin RNA in treatment of cancer
AssigneeOklahoma Medical Research Foundation
InventorEldon R. Jupe
Life of this patent
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AssigneeOklahoma Medical Research Foundation
InventorEldon R. Jupe
Estimating the term…
It has now been found that the introduction of single stranded oligonucleotides of DNA or RNA, particularly RNA transcribed from portions of wild type prohibitin 3′UTR, into tumors leads to arrested cell proliferation. Significant reduction in the size of primary tumors has been observed following direct administration of prohibitin 3′UTR RNA. Induction of systemic immunity, as evidenced by the disappearance of metastases as well as the lack of tumor growth in rechallenged animals following prohibitin RNA therapy, has been observed. Thus, wild type RNAs transcribed from portions of a prohibitin 3′UTR, or single stranded DNAs comprised of portions of a prohibitin 3′UTR, or synthetically-made oligonucleotides of the same sequences, can be directly administered as therapeutic agents against tumors.
An oligonucleotide derived from a portion of the 3′ untranslated region of a prohibitin gene.
A pharmaceutical preparation adapted for administration to obtain an antitumor effect, comprising a proliferation-inhibiting amount of an oligonucleotide derived from a portion of the 3′ untranslated region of a prohibitin gene, said preparation having proliferation-inhibiting activity in animals.
A method of inhibiting the proliferation of cancer cells comprising contracting cancer cells with a proliferation-inhibiting amount of an oligonucleotide derived from a portion of the 3′ untranslated region of the prohibitin gene, whereby proliferation of said cancer cells is inhibited.
A method for preparing a pharmaceutical composition for use in inhibiting proliferation of cancer cells, the method comprising formulating a proliferation-inhibiting amount of an oligonucleotide derived from a 3′ untranslated region of a prohibitin gene with isotonic saline.
A method for preparing a pharmaceutical composition for use in inhibiting proliferation of cancer cells, the method comprises formulating a proliferation-inhibiting amount of an oligonucleotide derived from a 3′ untranslated region of a prohibitin gene with DOTAP.
The DNA of SEQ ID NO:1.
The DNA of SEQ ID NO:2.
The DNA of SEQ ID NO:3, from about base 23 to base 260.
Dependencies are inferred from the claim text.