Oligonucleotide probes and primers comprising universal bases for therapeutic purposes
OwnerBob D. Brown, Timothy A. Rileyinventors
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Abstract
Aspects of the invention relate novel oligonucleotides comprising universal and/or generic bases, in particular juxtaposed universal and/or generic bases, which can be used to treat or prevent disease.
Claims20
An improved antisense oligonucleotide, which comprises a domain that recruits an RNase, and inhibits the function of a gene associated with a human disease, wherein the improvement comprises the incorporation of at least two juxtaposed universal bases in said oligonucleotide.
A method of inhibiting the function of a gene associated with a human disease comprising contacting a cell containing said gene with the improved antisense oligonucleotide comprising at least two juxtaposed universal bases, whereby the function of the gene in said cell is inhibited.
A method of inhibiting the function of a gene associated with a human disease comprising:
- providing an antisense oligonucleotide comprising a domain that recriuts an RNase and at least 2 juxtaposed universal bases;
- contacting a cell that expresses said gene with said antisense oligonucleotide whereby said contact inhibits the function of said gene.
Dependencies are inferred from the claim text.