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US 2003/0171311 A1Published application
Enzymatic nucleic acid treatment of diseases or conditions related to hepatitis C virus infection
OwnerLawrence Blatt, James McSwiggen +3inventors
InventorsLawrence Blatt, James McSwiggen, Elisabeth Roberts, Pamela A. Pavco, Dennis MacJack
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Abstract
The present invention relates to compounds, including enzymatic nucleic acid molecules, ribozymes, DNAzymes, nuclease activating compounds and chimeras such as 2′,5′-adenylates, that modulate the expression and/or replication of hepatitis C virus (HCV).
Claims42
A compound having Formula I:
- 3
- wherein X1 is an integer of 1, 2, or 3;
- X2 is an integer greater than or equal to 1;
- R6 independently represents a 3′-ribofuranose sugar moiety;
- each R1 and R2 independently represent non-bridging phosphate moieties;
- each R3, R4 and R8 independently represent a bridging phosphate moiety;
- and R5 represents an alkyl or alkylamine group, or an oligonucleotide comprising any of SEQ ID NOs. 4798-9637, an oligonucleotide having a sequence complementary to a sequence comprising SEQ ID NOs. 1-4556, or abasic moiety.
4 more elements
Dependencies are inferred from the claim text.