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US 2003/0171307 A1Published application
Azalide antibiotic compositions
AssigneePfizer Inc.
InventorWayne A. Boettner
Life of this patent
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Abstract
Antibiotic compositions comprising an equilibrium mixture of azalide isomers, water, and one or more acids, and methods for preparing such compositions, are disclosed. The antibiotic compositions can be advantageously stabilized by adding one or more water-miscible co-solvents. In a preferred embodiment, the one or more co-solvents is propylene glycol.
Claims30
A composition comprising:
- (a) a mixture of:
- (i) the compound of formula (I):
- 11
- and the compound of formula (II):
- 12
- in a ratio of about 90%±4% to about 10%±4%, respectively;
- (ii) water;
- and
- (iii) one or more acids to provide a pH of the composition of from about 4.5 to about 6.5;
- and
- (b) propylene glycol in an amount greater than about 25% by weight relative to the total volume.
8 more elements
Dependencies are inferred from the claim text.