Cancer treatment method
OwnerStephen Thomas Davis, Inderjit Kumar Dev +2inventors
InventorsStephen Thomas Davis, Inderjit Kumar Dev, Ronna Ellen Dornsife, John Gordon Gray
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Abstract
The invention relates to a method for treating cancer including administering to a mammal therapeutically effective amounts of an anti-neoplastic agent and a PDE4 inhibitor, treatment combinations containing the same as well as a method for attenuating unwanted cancer treatment side effects including myelosuppression and mucositis.
Claims54
A method of treating cancer in a mammal, comprising:
- administering to said mammal therapeutically effective amounts of (i) an anti-neoplastic agent which has an adverse effect on normal progenitor cells upon use;
- and (ii) a PDE4 inhibitor.
A method of treating cancer in a mammal, comprising:
- administering to said mammal therapeutically effective amounts of (i) paclitaxel;
- and (ii) cis-4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid or salt thereof.
A method of treating cancer in a mammal, comprising:
- administering to said mammal therapeutically effective amounts of (i) topotecan;
- and (ii) cis-4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid or salt thereof.
A cancer treatment combination, comprising:
- therapeutically effective amounts of (i) an anti-neoplastic agent that adversely affects normal progenitor cells upon use;
- and (ii) a PDE4 inhibitor.
A cancer treatment combination, comprising:
- therapeutically effective amounts of (i) paclitaxel;
- and (ii) cis-4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid or salt thereof.
A cancer treatment combination, comprising:
- therapeutically effective amounts of (i) topotecan;
- and (ii) cis-4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid or salt thereof.
A method of attenuating, in a mammal, cancer treatment side effects on normal progenitor cells in the mammal, comprising:
- administering to the mammal a therapeutically effective amount of a PDE4 inhibitor.
Use of (i) an anti-neoplastic agent that has an adverse effect on normal progenitor cells upon use;
- and (ii) a PDE4 inhibitor in the preparation of a medicament for the treatment of cancer.
Use of a PDE4 inhibitor for preparing a medicament for attenuating cancer treatment side effects on normal progenitor cells.
A method of treating cancer in a mammal, comprising:
- administering to the mammal a therapeutically effective amount of a PDE4 inhibitor.
Dependencies are inferred from the claim text.