Tetraphenylbacteriochlorin derivatives and compositions containing the same
AssigneesSan-Ei Gen F.F.I., Inc., Shigenobu Yano
InventorsShigenobu Yano, Toyoji Kakuchi, Yuji Mikata
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Abstract
Provided is a tetraphenylbacteriochlorin derivative represented by the formula (I): 1 [wherein R1, R2, R3 and R4, independently from each other, are a residue of a monosaccharide represented by the formulae: 2 (wherein, R is a hydrogen or a protecting group)], or its salt. The tetraphenylbacteriochlorin derivative or its salt has a large molar extinction coefficient at long wavelengths which are expected to have a high tissue-penetrating property, and exhibits high selectivity to tumor cells and hydrophilicity.
Claims7
A tetraphenylbacteriochlorin derivative represented by the formula (I):
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- [wherein, R1, R2, R3 and R4, independently from each other, are residues of mono-saccharides represented by the formulae:
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- (wherein R is a hydrogen atom or a protecting group)], or its salt.
A process for preparing a tetraphenylporphyrin derivative (IV) comprising reacting pyrrole with a bensaldehyde derivative represented by the formula (III):
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- [wherein R′ is a hydrogen atom, an alkyl group or a residue of a monosaccharide represented by the formula:
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- (wherein R is a hydrogen atom or a protecting group)] in the presence of a metal compound containing a metal selected from the group I transition metals of the periodic table of elements, to obtain a tetraphenylporphyrin derivative represented by the formula (IV):
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- (wherein M represents a metal selected from the group 1 transition metals of the periodic table and R′ is as defined above).
Dependencies are inferred from the claim text.