Chemically-modified human growth hormone conjugates
OwnerRory F. Finn, Wei Liao +1inventors
InventorsRory F. Finn, Wei Liao, Ned R. Siegel
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Abstract
The present invention provides a chemically modified human Growth Hormone (hGH) prepared by binding a water soluble polymer to the protein. The chemically-modified protein according to the present invention may have a much longer lasting hGH activity than that of the un-modified hGH, enabling reduced dose and scheduling opportunities.
Claims79
A conjugate comprising at least one water-soluble polymer molecule covalently attached to at least one amino acid residue of a biologically active human growth hormone (hGH) polypeptide or agonist variant thereof.
A human growth hormone-PEG conjugate having the structure
- 26
- wherein R is a human growth hormone polypeptide.
48 The conjugate of claim 46 wherein at least 90% of said polyethylene glycol is conjugated to the amino-terminal phenylalanine.
A human growth hormone-PEG conjugate having the structure
- 27
- wherein R is a human growth hormone polypeptide.
A human growth hormone-PEG conjugate having the structure
- mPEG-OCH2CH2CH2NH—R
- wherein R is a human growth hormone polypeptide.
The method of claim,63 wherein said growth or development disorder is Turner's syndrome.
A composition comprising the hGH of claim 48 and at least one pharmaceutically acceptable carrier.
A method of treating a patient having a growth or development disorder or comprising administering to said patient a therapeutically effective amount of the hGH conjugate of claim 48.
Dependencies are inferred from the claim text.