Antimicrobial cationic peptides and formulations thereof
AssigneeMicrologix Biotech Inc.
InventorsTimothy J. Krieger, Patricia J. McNicol, Janet R. Fraser
Life of this patent
Estimating the term…
Abstract
Compositions and methods for making and using therapeutic formulations of antimicrobial cationic peptides are provided. The antimicrobial cationic peptide formulations may be used, for example, in the treatment of microorganism-caused infections, which infections may be systemic, such as a septicemia, or may be localized, such as in acne or an implanted or indwelling medical device.
Claims192
A composition, comprising an antimicrobial cationic peptide, a viscosity-increasing agent, and a solvent.
A composition, comprising an antimicrobial cationic peptide, a viscosity-increasing agent, a solvent, a humectant, and a buffering agent.
A composition, comprising an antimicrobial cationic peptide, a buffering agent, and a solvent.
A composition, comprising an antimicrobial cationic peptide at a concentration ranging from about 0.01% to about 10%;
- a viscosity-increasing agent selected from the group consisting of dextran, polyvinylpyrrolidone, hydroxyethyl cellulose, and hydroxypropyl methylcellulose;
- and a solvent selected from the group consisting of water, glycerin, propylene glycol, isopropanol, ethanol, and methanol;
- at a pH ranging from about 3 to about 8.
A composition, comprising:
- a) an antimicrobial cationic peptide wherein the cationic peptide is a peptide of up to 35 amino acids, comprising one of the following sequences:
- 11B7CN, 11B32CN, 11B36CN, 11E3CN, 11F4CN, 11F5CN, 11F12CN, 11F17CN, 11F27CN, 11F50CN, 11F56CN, 11F63CN, 11F64CN, 11F66CN, 11F67CN, 11F68CN, 11F93CN, 11G27CN, 11J02CN, 11J02ACN, 11J30CN, 11J36CN, 11J58CN, Nt-acryloyl-11B7CN, Nt-glucosyl-11J36CN, or Nt-glucosyl-11J38CN;
- b) a viscosity-increasing agent wherein the viscosity-increasing agent is hydroxyethyl cellulose at a concentration of about 1.2% to about 1.8%;
- c) a buffer wherein the buffer is lactate at a concentration ranging from about 4 mM to about 6 mM;
- d) a solvent wherein the solvent comprises glycerin at a concentration ranging from about 9% to about 11% and water at a concentration ranging from about 85% to about 90%;
- and
- e) a pH ranging from about 3.5 to about 7.
A composition, comprising:
- a) an antimicrobial cationic peptide wherein the cationic peptide is a peptide of up to 35 amino acids, comprising one of the following sequences:
- 11B7CN, 11B32CN, 11B36CN, 11E3CN, 11F4CN, 11F5CN, 11F12CN, 11F17CN, 11F27CN, 11F50CN, 11F56CN, 11F63CN, 11F64CN, 11F66CN, 11F67CN, 11F68CN, 11F93CN, 11G27CN, 11J02CN, 11J02ACN, 11J30CN, 11J36CN, 11J58CN, Nt-acryloyl-11B7CN, Nt-glucosyl-11J36CN, or Nt-glucosyl-11J38CN;
- b) a buffer wherein the buffer is lactate at a concentration ranging from about 4 mM to about 6 mM;
- c) a solvent wherein the solvent comprises ethanol at a concentration ranging from about 45% to about 55% and water at a concentration ranging from about 44% to about 54%;
- and
- d) a pH ranging from about 3.5 to about 7.
A composition, comprising:
- a) an antimicrobial cationic peptide wherein the cationic peptide is a peptide of up to 35 amino acids, comprising one of the following sequences:
- 11B7CN, 11B32CN, 11B36CN, 11E3CN, 11F4CN, 11F5CN, 11F12CN, 11F17CN, 11F27CN, 11F50CN, 11F56CN, 11F63CN, 11F64CN, 11F66CN, 11F67CN, 11F68CN, 11F93CN, 11G27CN, 11J02CN, 11J02ACN, 11J30CN, 11J36CN, 11J58CN, Nt-acryloyl-11B7CN, Nt-glucosyl-11J36CN, or Nt-glucosyl-11J38CN;
- b) a viscosity-increasing agent wherein the viscosity-increasing agent is hydroxyethyl cellulose at a concentration of about 1.2% to about 1.8%;
- c) a solvent wherein the solvent comprises glycerin at a concentration ranging from about 9% to about 11% and water at a concentration ranging from about 85% to about 90%;
- d) a preservative wherein the preservative is benzoic acid at a concentration ranging from about 20 mM to about 30 mM;
- and
- e) a pH ranging from about 3.5 to about 4.7.
A method for reducing microflora at a target site, comprising applying to the target site a composition comprising an antimicrobial cationic peptide, a viscosity-increasing agent, and a solvent.
A method for treating or preventing infection at a target site, comprising applying to the target site a composition comprising a cationic peptide, a viscosity-increasing agent, and a solvent.
Dependencies are inferred from the claim text.