Compositions and methods for modulation of immune responses
OwnerKarl Petter Soderstrominventor
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Abstract
The present invention relates to a novel mechanism for modulation of immune response. More closely, the present invention relates to modulation of CD94/NKG2 receptor function by HLA-E+bound peptides causing either inhibition or absence of inhibition of said receptors. In a preferred embodiment the invention relates to HLA-E binding hsp (heat shock protein) 60 peptides.
Claims12
Use of an HLA-E binding peptide in medicine, wherein said peptide modulates the effect of CD94/NKG2 cell receptors.
A peptide selected from:
- VMAPVTVLL and QMRPRSRVL
A peptide according to any of the above claims in complex with HLA-E.
An assay for HLA-E binding peptides or analogues, comprising the steps:
- a) providing a peptide library;
- b) forming HLA-E/peptide complexes;
- c) selecting stable complexes capable of inhibiting or activating CD94/NKG2 receptors on NK and T cells;
- and
- d) isolation of a stable peptide/peptide analogue from said complex.
Dependencies are inferred from the claim text.