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US 2003/0171278 A1Published application
Compounds that bind HER2
AssigneeGenentech, Inc.
InventorMark S. Dennis
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Abstract
The invention provides novel compounds which bind to the human erbB2 gene product (ErbB2, also known as HER2, or c-ErbB-2). In particular aspects, the invention provides for the treatment of disorders characterized by the overexpression of ErbB2 utilizing the novel compounds of the invention. The invention also provides pharmaceutical compositions comprising the novel compounds as well as for their use in research, diagnostic, therapeutic, and prophylactic methods.
Claims38
A non-naturally occurring peptide ligand which competes for binding HER2 in an in vitro assay with a peptide ligand having the formula:
- Xaa(1-14)-Cys-Xaa6-Gly-Pro-Gly-Cys-Xaa(21-27) (SEQ ID NO:
- 90)
- wherein X(1-14) is absent or between one and fourteen amino acids;
- Xaa16 is an amino acid selected from the group consisting of Met, Thr, Cys and Ile and Xaa(21-27) is absent or between one and 7 amino acids.
1 more element
Dependencies are inferred from the claim text.