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AssigneeThe Regents of the University of California
InventorsOlivier Civelli, Steven Lin
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The invention provides a substantially pure Prolactin Releasing Peptide (PrRP) functional analog which suppresses absence seizures in a mammal, and related pharmaceutical compositions. The invention also provides a method of controlling absence seizures in a mammal, by administering to a mammal susceptible to absence seizures an effective amount of PrRP or a PrRP functional analog. Also provided are methods of identifying a compound that modulates AMPA receptor signaling in a mammal, by providing a compound that is a PrRP or PrRP functional analog, and determining the ability of the compound to modulate AMPA receptor signaling. The invention also provides methods of identifying a compound for controlling absence seizures in a mammal, by providing a compound that is a PrRP or PrRP functional analog, and determining the ability of the compound to control absence seizures in a mammal. Also provided are pharmaceutical compositions for controlling absence seizures in a mamma. The compositions and related methods contain a compound identified by the methods of the invention as a compound that modulates AMPA receptor signaling or as a compound that controls absence seizures.
A substantially pure Prolactin Releasing Peptide (PrRP) functional analog, which suppresses absence seizures in a mammal.
A pharmaceutical composition, comprising PrRP and a second compound which suppresses absence seizures.
A method of controlling absence seizures in a mammal, comprising administering to a mammal susceptible to absence seizures an effective amount of PrRP or a PrRP functional analog.
A method of identifying a compound that modulates AMPA receptor signaling in a mammal, comprising:
A method of identifying a compound for controlling absence seizures in a mammal, comprising:
Dependencies are inferred from the claim text.