Drug complex
AssigneeDaiichi Pharmaceutical Co., Ltd.
InventorsKazuhiro Inoue, Hiroshi Susaki, Masahiro Ikeda, Hiroshi Kuga, Eiji Kumazawa, Akiko Togo
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Abstract
A drug complex characterized in that a residue of a drug compound such as antineoplastic agents and a carboxy(C1-4)alkyldextran polyalcohol obtained by treating a dextran under conditions that enable substantially complete polyalcoholization are bound to each other by means of a spacer comprising an amino acid or a spacer comprising peptide-bonded 2 to 8 amino acids. Said complex is characterized in that it has excellent selectivity to tumorous sites so as to exhibit high antineoplastic activity and also achieves reduced appearance of toxicity.
Claims26
A drug complex characterized in that a carboxy(C1-4)alkyldextran polyalcohol and a residue of a drug compound are bound to each other by means of a spacer comprising an amino acid or a spacer comprising peptide-bonded 2 to 8 amino acids.
A drug delivery carrier for binding a drug compound which comprises a carboxy(C1-4)alkyldextran polyalcohol.
A use of a carboxy(C1-4)alkyldextran polyalcohol for a manufacture of a drug complex containing the carboxy(C1-4)alkyldextran polyalcohol bound to a residue of a drug compound.
A use of a carboxy(C1-4)alkyldextran polyalcohol for a manufacture of a drug complex in which a residue of a drug compound and the carboxy(C1-4)alkyldextran polyalcohol are bound to each other by means of a spacer or without a spacer.
Dependencies are inferred from the claim text.