Particle based vaccine composition
OwnerHazire Oya Alpar, Ethel Diane Williamson +1inventors
InventorsHazire Oya Alpar, Ethel Diane Williamson, Leslie William James Baillie
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Abstract
A pharmaceutical composition which comprises microparticles comprising (i) a biologically active compound capable of generating an immune response in an animal to which it is administered which is protective against a pathogen; (ii) a polymeric material capable of forming microspheres; and (iii) an immunostimulant comprising a phospholipid. The composition is particularly useful for the oral administration of vaccines.
Claims28
A pharmaceutical composition which comprises microparticles comprising
- (i) a biologically active compound capable of generating an immune response;
- (ii) a polymeric material capable of forming microspheres;
- and
- (iii) an immunostimulant comprising a phospholipid.
A composition according to any one of the preceding claims wherein the polymeric material is a high molecular weight polymer.
A composition according to any one of the preceding claims wherein the polymeric material comprises a poly(hydroxy)acid or or a copolymer thereof.
A composition according to any one of the preceding claims wherein the phospholipid is selected from lecithin or its precursor phosphoryl choline, distearylphosphatidylcholine (DSPC) and phosphatidinylserine (PS).
A composition according to any one of the preceding claims which contains from 0.1% to 20% w/w phospholipid.
A composition according to any one of the preceding claims wherein the biologically active compound capable of generating an immune response in an animal to which it is administered comprises a polypeptide or a nucleic acid.
A composition according to any one of the preceding claims which further comprises a preservative.
A composition according to any one of the preceding claims wherein the microspheres used in the compositions may further comprise an S-layer proteins.
A composition according to any one of the preceding claims wherein the microspheres are suspended in a diluent or carrier.
A composition according to any one of the preceding claims wherein the ratio of the polymeric material to the phospholipid is from 99:1 to 9:1% w/w.
A phospholipid for use as an immunostimulant.
The use of a phospholipid as an immunostimulant in the production of a vaccine for use in prophylactic or therapeutic treatment.
Dependencies are inferred from the claim text.