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US 2003/0171256 A1Published application
Enzymatic treatment of whey proteins for the production of antihypertensive peptides, the resulting products and treatment of hypertension in mammals
OwnerMartin E. Davis, Anand Rao +4inventors
InventorsMartin E. Davis, Anand Rao, Sylvie Gauthier, Yves Pouliot, Line Gourley, Anne-Francoise Allain
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Abstract
Enzymatic digests of whey protein concentrates were prepared using animal, bacterial and fungal proteases, and evaluated for antihypertensive activities. ACE-inhibitory activity and antihypertension activity were obtained with a hydrolysate of whey protein isolate prepared with a porcine trypsin.
Claims14
A process for preparing an ACE-suppressing composition comprising:
- preparing an aqueous solution of whey protein isolate and a proteolytic enzyme;
- holding said solution under conditions effective to partially hydrolyze said whey protein isolate to provide a hydrolysate having increased ACE-suppressing activity in mammals;
- and
- recovering said hydrolysate from said solution.
1 more element
A treatment regimen for a mammal to reduce symptoms of hypertension, said regimen comprising:
- orally administering to the mammal, a whey protein hydrolysate prepared by treatment of a whey protein isolate as described, in amounts and at intervals effective to reduce symptoms of hypertension.
Dependencies are inferred from the claim text.