Dissociative fluorescence enhancement assay
AssigneeWallac Oy
InventorsIlkka Hemmila, Kaj Blomberg, Veli-Matti Mukkala, Harri Hakala
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Abstract
The invention relates to an enhancement solution for an assay technology using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection, wherein said enhancement solution comprises a β-dietone of formula I 1 wherein R1 is an aryl, optionally mono- or multi-substituted, and R2 is a straight or branched alkyl chain with 2 to 9 carbon atoms substituted with four or more fluorine atoms. The invention further relates to a bioaffinity assay using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection comprising the use of said enhancement solution.
Claims26
An enhancement solution for an assay technology using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection, wherein said enhancement solution comprises a β-diketone of formula I
- 4
- wherein
- R1 is an aryl, optionally mono- or multi-substituted, and
- R2 is a straight or branched alkyl chain with 2 to 9 carbon atoms substituted with four or more fluorine atoms optionally mono- or multi-substituted with other substituents than fluorine.
Dependencies are inferred from the claim text.