US 2003/0170891 A1 · RNA interference mediated inhibition of epidermal growth factor receptor gene expression using short interfering nucleic acid (siNA)

Abstract

The present invention concerns methods and reagents useful in modulating EGFR (HER1, HER2, HER3, and/or HER4) gene expression in a variety of applications, including use in therapeutic, diagnostic, agricultural, target validation, and genomic discovery applications. Specifically, the invention relates to short interfering nucleic acid (siNA) or short interfering RNA (siRNA) molecules capable of mediating RNA interference (RNAi) against epidermal growth factor receptor targets.

Claims34

Dependent claims

A short interfering nucleic acid (siNA) molecule that down regulates expression of an EGFR gene by RNA interference.

Dependencies are inferred from the claim text.

Facts

Application

10/251,117Filed 19 Sep 2002

Priority

6 Jun 2001

Published

11 Sep 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification5 codes

C07H 21/02
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of…: with…
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61K 47/54
The non-active ingredient being a modifying agent: the modifying agent being an organic compound
C07H
Sugars

Family

Application60/296,249Us provisional application · filed 6 Jun 2001

Application09/916,466Continuation in part · filed 25 Jul 2001

Application60/358,580Us provisional application · filed 20 Feb 2002

Application10/163,552Continuation in part · filed 6 Jun 2002

Application60/393,924Us provisional application · filed 3 Jul 2002

Application10/251,117Continuation in part · filed 19 Sep 2002

US 2003/0064945 A1Published application

US 2003/0105051 A1Published application

US 2003/0170891 A1This patent

From the US filing history. Foreign family members aren’t listed.

Abstract

Facts

Application

10/251,117Filed 19 Sep 2002

Priority

6 Jun 2001

Published

11 Sep 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification5 codes

C07H 21/02
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of…: with…
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61K 47/54
The non-active ingredient being a modifying agent: the modifying agent being an organic compound
C07H
Sugars

Family

Application60/296,249Us provisional application · filed 6 Jun 2001

Application09/916,466Continuation in part · filed 25 Jul 2001

Application60/358,580Us provisional application · filed 20 Feb 2002

Application10/163,552Continuation in part · filed 6 Jun 2002

Application60/393,924Us provisional application · filed 3 Jul 2002

Application10/251,117Continuation in part · filed 19 Sep 2002

US 2003/0064945 A1Published application

US 2003/0105051 A1Published application

US 2003/0170891 A1This patent

From the US filing history. Foreign family members aren’t listed.

RNA interference mediated inhibition of epidermal growth factor receptor gene expression using short interfering nucleic acid (siNA)

Life of this patent

Abstract

Claims34

RNA interference mediated inhibition of epidermal growth factor receptor gene expression using short interfering nucleic acid (siNA)

Life of this patent

Abstract

Claims34