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AssigneeDana-Farber Cancer Institute, Inc.
InventorsGordon J. Freeman, Arnold S. Freedman, Lee M. Nadler
Estimating the term…
Isolated nucleic acid molecules encoding a B cell activation antigen, B7, are provided. In one embodiment, the nucleic acid molecules are DNA sequences. The DNA sequences of the invention can be integrated into various expression vectors, which in turn can direct the synthesis of the corresponding proteins or peptides in a variety of hosts, particularly eukaryotic cells, such as mammalian and insect cell culture. Also provided are host cells transformed to produce proteins or peptides encoded by the DNA molecules of the present invention and purified proteins and peptides which comprise at least a portion of the B cell activation antigen. The proteins and peptides comprise at least a portion of the mature form of the B7 activation antigen and preferably comprise a soluble form of the B7 protein.
An isolated nucleic acid sequence coding for B lymphocyte activation antigen, B7.
A substantially pure nucleic acid sequence coding for at least a portion of the coding region of the B7 B lymphocyte activation antigen set forth in SEQ ID NO:2 comprising amino acids −34 to 254.
A substantially pure nucleic acid sequence coding for a B7 activation antigen which is identical with at least about 40% of the amino acids sequence set forth in SEQ ID NO:2 comprising amino acids −1 to 254.
A substantially pure nucleic acid sequence comprising the nucleic acid sequence substantially as shown in SEQ ID NO:1 encoding a human B7 activation antigen.
A substantially pure nucleic acid sequence comprising the nucleic acid sequence substantially as shown in SEQ ID NO:3 encoding a murine B7 activation antigen.
A substantially pure B7 protein.
Dependencies are inferred from the claim text.