Methods and materials relating to novel prothrombinase-like polypeptides and polynucleotides
OwnerDana A. Haley, Bryan J. Boyle +3inventors
InventorsDana A. Haley, Bryan J. Boyle, Alice S. Ho, Matthew C. Arterburn, Nancy K. Mize
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Abstract
The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human prothrombinase-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human ovary (Hyseq clone identification number 7735656). Other aspects of the invention include vectors containing processes for producing novel human prothrombinase-like polypeptides, and antibodies specific for such polypeptides.
Claims30
An isolated polynucleotide with human prothrombinase activity comprising a nucleotide sequence of SEQ ID NO:
- 2 or 3, the mature protein coding portion thereof, or the active domain thereof.
An isolated polypeptide comprising an amino acid selected from the group consisting of SEQ ID NO:
- 4-9, the mature protein portion thereof, and active domain thereof.
A polypeptide having prothrombinase activity comprising at least ten consecutive amino acids from the group consisting of SEQ ID NO:
- 4-9.
The polypeptide of claim 26, comprising at least five consecutive amino acids from the group consisting of SEQ ID NO:
- 4-9.
An isolated polypeptide with prothrombinase activity having at least an amino acid sequence of SEQ ID NO:
- 9, wherein A=Alanine, C=Cysteine, D=Aspartic Acid, E=Glutamic Acid, F=Phenylalanine, G=Glycine, H=Histidine, I=Isoleucine, K=Lysine, L=Leucine, M=Methionine, N=Asparagine, P=Proline, Q=Glutamine, R=Arginine, S=Serine, T=Threonine, V=Valine, W=Tryptophan, Y=Tyrosine.
Dependencies are inferred from the claim text.