Novel genes involved in the control of hematopoiesis
OwnerMichael Paul Cooke, Claire Louise Holness +1inventors
InventorsMichael Paul Cooke, Claire Louise Holness, Oksana Ivanivna Sirenko
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Abstract
The present invention provides three novel HSC genes designated SCM 3, SCM 26, and SCM 113, the coding regions thereof, the gene products, applications of the genes, DNA constructs, vectors and transformed cells each comprising the gene or a fragment thereof. Methods of using the SCM 3, SCM 26 and SCM 113 polynucleotide and polypeptide sequences are also disclosed.
Claims34
An isolated nucleic acid molecule comprising a polynucleotide sequence encoding a polypeptide that blocks differentiation of mammalian hematopoietic stem cells, wherein said polypeptide comprises an amino acid sequence selected from the group consisting of:
- a) an amino acid sequence at least 85% identical to SEQ ID NO:2;
- b) an amino acid sequence at least 85% identical to SEQ ID NO:4;
- c) an amino acid sequence at least 85% identical to residues 240-543 of SEQ ID NO:4;
- and
- d) an amino acid sequence at least 85% identical to SEQ ID NO:6.
An isolated polypeptide that blocks differentiation of mammalian hematopoietic stem cells, wherein said polypeptide comprises an amino acid sequence selected from the group consisting of:
- a) an amino acid sequence at least 85% identical to SEQ ID NO:2;
- b) an amino acid sequence at least 85% identical to either SEQ ID NO:4 or to residues 240-543 of SEQ ID NO:4;
- and
- c) an amino acid sequence at least 85% identical to SEQ ID NO:6.
Dependencies are inferred from the claim text.