Method to extend the life span of normal cells
OwnerRenu Wadhwainventor
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Abstract
The present inventors discovered that the life span of human normal diploid pulmonary fibroblasts MRC-5 could be extended by intracellular expression of mot-2. The use of mot-2 enables the immortalization of cells and/or the extension of the cell life span without transformation. The method of the present invention is applicable to the establishment of normal liver cells for producing albumin, and such.
Claims26
A method of increasing the life span of a cell that normally undergoes senescence, the method comprising the step of increasing the level of mortalin-2 in the cell.
A method of increasing the life span of a cell that normally undergoes senescence, the method comprising administering a mortalin-2 encoding nucleic acid to the cell.
A method of producing albumin, the method comprising:
- (a) obtaining a liver cell comprising an exogenous mortalin-2 encoding nucleic acid;
- (b) allowing the liver cell to express an albumin;
- and
- (c) collecting the albumin from the liver cell, thereby producing albumin.
The method of claim 25, wherein the mortalin 2 is human mortalin 2A or mortalin 2B.
A method of producing albumin, the method comprising:
- (a) administering to a liver cell a compound that increases expression or activity of endogenous mortalin-2;
- (b) allowing the liver cell to express an albumin;
- and
- (c) collecting the albumin from the liver cell, thereby producing albumin.
Dependencies are inferred from the claim text.