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US 2003/0170762 A1Published application
Compounds for generating chemiluminescence with a peroxidase
AssigneeLumigen, Inc.
InventorsHashem Akhavan-Tafti, Renuka de Silva, Wenhua Xie
Life of this patent
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Abstract
Novel compounds comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence rapidly by reaction with a peroxidase enzyme and a peroxide. The chemiluminescence thus produced can be used as a detectable signal in assays for peroxidase enzymes or peroxide-producing enzymes and in assays employing enzyme-labeled specific binding pairs.
Claims20
A compound of the formula:
- 26
- wherein R1 and R2 are independently selected from alkyl, substituted alkyl, aryl, substituted aryl, aralkyl and substituted aralkyl groups of 1-20 carbon atoms and can be joined together to form a ring, each of R4 to R11 is independently a substituent which can contain from 1 to 50 atoms selected from C, H, N, O, S, P, Si and halogen atoms, and R3 is selected from alkyl, substituted alkyl, aryl, substituted aryl, aralkyl and substituted aralkyl groups.
Dependencies are inferred from the claim text.