Monoclonal antibodies specific for neoplasia-specific NADH:disulfide reductase
AssigneePurdue Research Foundation
InventorsD. James Morre, NaMi McCarty, Dorothy Morre, Pin-Ju Chueh
Life of this patent
Estimating the term…
Abstract
Compositions and methods for diagnosis of neoplastic tissue are described. Monoclonal antibodies which specifically recognize the tumor cell specific NADH:protein thiol reductase and the hybridoma cell lines which produce them are provided. Also provided are diagnostic and immunohistological assays for the identification of cells that are neoplastic. Because the antibodies specifically prevent the growth of cancer cells, induce apoptotic cell death of cancer cells, and are without effect on normal cells, the described monoclonal antibodies are useful for inhibiting cancer cell growth and for treating a neoplastic condition.
Claims15
A monoclonal antibody specific for a disulfide-thiol interchange/NADH oxidase protein activity site of a cell surface protein (tNOX), wherein said tNOX occurs in serum, in urine and on surfaces of neoplastic cells of a human or animal with a neoplastic disorder and does not occur in serum, urine and cell surfaces of a human or animal without a neoplastic disorder.
A method for producing an anti-idiotypic monoclonal antibody to a monoclonal antibody which specifically binds to a cancer-specific epitope of tNOX, said method comprising the step of immunizing a human or animal with said monoclonal antibody and selecting anti-idiotypic antibodies.
Dependencies are inferred from the claim text.