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US 2003/0170742 A1Published application
Polynucleotides and polypeptides associated with the development of rheumatoid arthritis
AssigneeBristol-Myers Squibb Company
InventorsJulie Carman, Steven G. Nadler, Michael Bowen, Michael G. Neubauer, Pin Lu
Life of this patent
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Abstract
The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.
Claims36
An assay for identifying a compound that modulates the activity of a gene associated with rheumatoid arthritis, comprising:
- (1) providing a cell expressing a gene associated with rheumatoid arthritis, wherein the nucleic acid sequence of said gene associated with rheumatoid arthritis is at least 95% identical to a nucleic acid sequence selected from the group consisting of SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:70, SEQ ID NO:71, SEQ ID NO:73 and SEQ ID NO:74;
- (2) contacting said cell expressing said gene associated with rheumatoid arthritis with a test compound;
- and
- (3) determining whether said test compound modulates the activity of said gene associated with rheumatoid arthritis.
1 more element
An assay for identifying a compound that modulates the activity of a protein associated with rheumatoid arthritis, comprising:
- (1) providing a cell expressing a gene associated with rheumatoid arthritis, wherein said gene encodes a polypeptide having an amino acid sequence which is at least 95% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:72 and SEQ ID NO:75;
- (2) contacting said cell expressing said gene associated with rheumatoid arthritis with a test compound;
- and
- (3) determining whether said test compound modulates the activity of said protein associated with rheumatoid arthritis.
1 more element
A method for the treatment of rheumatoid arthritis, comprising:
- (1) identifying a patient suffering from rheumatoid arthritis;
- and
- (2) administering to said patient a therapeutically effective amount of a modulator of a gene associated with rheumatoid arthritis,
- wherein said gene associated with rheumatoid arthritis has a nucleic acid sequence which is at least 95% identical to a nucleic acid sequence selected from the group consisting of SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:70, SEQ ID NO:71, SEQ ID NO:73 and SEQ ID NO:74.
1 more element
A method for the treatment of rheumatoid arthritis, comprising:
- (1) identifying a patient suffering from rheumatoid arthritis;
- and
- (2) administering to said patient suffering from rheumatoid arthritis a therapeutically effective amount of a modulator of a polypeptide associated with rheumatoid arthritis,
- wherein said polypeptide associated with rheumatoid arthritis has an amino acid sequence which is at least 95% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:72 and SEQ ID NO:75.
1 more element
A method for the prevention of rheumatoid arthritis, comprising:
- (1) identifying a patient at risk for rheumatoid arthritis;
- and
- (2) administering to said patient at risk for rheumatoid arthritis a therapeutically effective amount of a modulator of a gene associated with rheumatoid arthritis,
- wherein said gene associated with rheumatoid arthritis has a nucleic acid sequence which is at least 95% identical to a nucleic acid sequence selected from the group consisting of SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:70, SEQ ID NO:71, SEQ ID NO:73 and SEQ ID NO:74.
1 more element
A method for the prevention of rheumatoid arthritis, comprising:
- (1) identifying a patient at risk for rheumatoid arthritis;
- and
- (2) administering to said patient at risk for rheumatoid arthritis a therapeutically effective amount of a modulator of a polypeptide associated with rheumatoid arthritis,
- wherein said polypeptide associated with rheumatoid arthritis has an amino acid sequence which is at least 95% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:72 and SEQ ID NO:75.
1 more element
A compound useful for the treatment of rheumatoid arthritis, wherein said compound is identified by:
- (1) providing a cell expressing a gene associated with rheumatoid arthritis,
- wherein said gene associated with rheumatoid arthritis has a nucleic acid sequence which is at least 95% identical to a nucleic acid sequence selected from the group consisting of SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:53, SEQ ID NO:55, SEQ ID NO:57, SEQ ID NO:59, SEQ ID NO:61, SEQ ID NO:63, SEQ ID NO:65, SEQ ID NO:67, SEQ ID NO:69, SEQ ID NO:70, SEQ ID NO:71, SEQ ID NO:73 and SEQ ID NO:74;
- (2) contacting said cell expressing said gene associated with rheumatoid arthritis with said compound;
- and
- (3) determining whether said compound modulates the activity of said gene associated with rheumatoid arthritis.
2 more elements
A compound useful for the treatment of rheumatoid arthritis, wherein said compound is identified by:
- (1) providing a cell expressing a polypeptide associated with rheumatoid arthritis,
- wherein said polypeptide associated with rheumatoid arthritis has an amino acid sequence which is at least 95% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:38, SEQ ID NO:40, SEQ ID NO:42, SEQ ID NO:44, SEQ ID NO:46, SEQ ID NO:48, SEQ ID NO:50, SEQ ID NO:52, SEQ ID NO:54, SEQ ID NO:56, SEQ ID NO:58, SEQ ID NO:60, SEQ ID NO:62, SEQ ID NO:64, SEQ ID NO:66, SEQ ID NO:68, SEQ ID NO:72 and SEQ ID NO:75;
- (2) contacting said cell expressing said polypeptide associated with rheumatoid arthritis with said compound;
- and
- (3) determining whether said compound modulates the activity of said polypeptide associated with rheumatoid arthritis.
2 more elements
Dependencies are inferred from the claim text.