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US 2003/0170733 A1Published application
Device and method for multiparallel synthesis and screening
AssigneeThe University of Chicago
InventorsSergey A. Kozmin, Ying Wang
Life of this patent
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Abstract
There is disclosed a device for multiparallel synthesis or screening of a chemical library that includes at least one, and preferably more than one, plate with a two-dimensional or three-dimensional array of wells. Openings are provided in the side walls between at least some of the wells, through which the fluid can flow between adjacent wells. At least one inlet for each plate is provided whereby fluids can be introduced into the array of wells in each plate and flow between adjacent wells in each of the plates through the openings in the side walls.
Claims56
A device for multiparallel synthesis or screening of a chemical library comprising:
- a plate comprising a two-dimensional array of wells for receiving fluids, each well comprising a bottom and side walls;
- and
- openings in the side walls between at least some of the wells, through which the fluids can flow between adjacent wells;
- and
- at least one inlet for the plate whereby fluids can be introduced into the array of wells in the plate and flow between adjacent wells through the openings in the side walls.
2 more elements
A device for multiparallel synthesis or screening comprising:
- an array comprising rows of wells for receiving fluids, each well comprising a bottom and side walls;
- openings in the side walls, the openings being aligned along each of the rows of wells;
- and
- at least one elongated element adapted to be inserted through at least some of the openings along at least one of the rows of wells;
- wherein a flow of fluids along the at least one of the rows of wells is controlled by the elongated element's reducing or closing the openings it passes through.
2 more elements
A device for multiparallel synthesis or screening comprising:
- an array comprising wells for receiving fluids, the wells being arranged in rows and columns, each of the wells comprising a bottom and side walls;
- a first set of openings in the side walls, the openings in the first set of openings being aligned along each of the rows;
- a second set of openings in the side walls, the openings in the second set of openings being aligned along each of the columns;
- a first set of elongated elements, each adapted to be inserted through the first set of openings in a single row;
- and
- a second set of elongated elements, each adapted to be inserted through the second set of openings in a single column;
- wherein a flow of fluids along each of the rows is controlled by one of the first set of elongated elements passing therethrough by reducing or closing one or more openings along each of the rows;
- and wherein the flow of fluids along each of the columns is controlled by one of the second set of elongated elements passing therethrough by reducing or closing one or more openings along each of the columns.
5 more elements
A device for multiparallel synthesis or screening comprising:
- (a) a three-dimensional array formed from at least two plates comprising a plurality of wells for receiving a fluid;
- and
- (b) means for introducing the fluid into a plurality of inlets at two or more adjacent surfaces of the three-dimensional array,
- wherein the fluid flows from a first of the plurality of wells to one or more other wells selected from the plurality of wells through openings in the plurality of wells, and a bottom portion of each of the plurality of wells is sealed to prevent the flow of the fluid from a well of a first plate to a well of a second plate.
1 more element
A device for multiparallel synthesis or screening comprising:
- (a) an array formed from at least two plates comprising a plurality of wells for receiving a fluid;
- and
- (b) means for allowing a flow of the fluid between at least two of the plurality of wells in a substantially parallel direction relative to a plane of one of the at least two plates,
- wherein the fluid is introduced through an opening on one side of the array, and the fluid flows from a first of the plurality of wells to one or more other wells selected from the plurality of wells through openings in one or more of the plurality of wells.
1 more element
A device for multiparallel synthesis or screening comprising:
- an array formed from at least two plates, each comprising a plurality of wells for receiving a fluid;
- and
- means for introducing a fluid into at least three sets of wells selected from the plurality of wells,
- wherein each set of wells is oriented perpendicularly relative to two of the three sets of wells, the fluid is introduced through an opening on one side of the array, and the fluid flows from a first of the plurality of wells to one or more other wells selected from the plurality of wells through openings in at least one of the plurality of wells.
1 more element
A device for multiparallel synthesis or screening comprising:
- (a) an array formed from at least two plates comprising a plurality of wells for receiving a fluid;
- (b) means for introducing the fluid into one or more of the plurality of wells;
- and
- (c) a plurality of removable sealing elements each of which extends between at least two openings in at least one of the plurality of wells when in a sealing position.
1 more element
A device for multiparallel synthesis or screening of a chemical library comprising:
- a three-dimensional array formed from at least two plates joined together, each plate comprising a two-dimensional array of wells for receiving fluids, the wells in each plate being formed into rows and columns, each well comprising at least a bottom and four side walls;
- openings in all four of the side walls of all of the wells in the arrays, a first set of the openings allowing fluids to flow between adjacent wells along at least one of the rows, and a second set of openings allowing fluids to flow between adjacent wells along at least one of the columns;
- and
- a first set of inlets for introducing fluids into each of the rows;
- and
- a second set of inlets for introducing fluids into each of the columns;
- wherein the first set of openings is adjacent the bottom of each of the wells and the second set of openings is adjacent an upper portion of each of the wells, and wherein the level of fluid in the wells is maintained below the second set of openings when the device is in a first orientation with the bottom of each of the wells below the upper portion of each of the wells, and the level of fluid in the wells is maintained below the first set of openings when the device is inverted to a second orientation with the upper portion of each of the wells below the bottom of each of the wells;
- thereby selectively allowing fluid communication between the wells in each of the rows but not between the wells in each of the columns when the device is in its first orientation, and allowing fluid communication between the wells in each of the columns but not between the wells in each of the rows when the device is inverted to its second orientation.
5 more elements
A device for multiparallel synthesis or screening comprising:
- a three-dimensional array comprising at least two plates, comprising wells for receiving fluids arranged in rows and columns, each well comprising a bottom and side walls;
- a first set of openings in the side walls, the openings in the first set of openings being aligned along each of the rows;
- a second set of openings in the side walls, the openings in the second set of openings being aligned along each of the columns;
- a first set of elongated elements, each adapted to be inserted through the first set of openings;
- and
- a second set of elongated elements, each adapted to be inserted through the second set of openings;
- wherein the flow of fluids along each of the rows is controlled by an elongated element of the first set passing therethrough by reducing or closing the openings therein;
- and wherein the flow of fluids along each of the columns is controlled by an elongated element of the second set passing therethrough by reducing or closing the openings therein.
5 more elements
A method for synthesizing or screening compounds comprising:
- introducing a first fluid into a plurality of wells of an array formed from at least two plates through at least one opening in each wall of the plurality of wells;
- and
- introducing a second fluid into the plurality of wells through the at least one opening in each wall of the plurality of wells,
- wherein a first and second fluid is introduced through an opening on one side of the array, and the first and second fluid flow from a first of the plurality of wells to one or more other wells selected from the plurality of wells in a substantially parallel direction relative to a plane of one of the at least two plates.
1 more element
A method for synthesizing or screening compounds comprising:
- introducing a fluid into a first set of wells of an array;
- introducing a fluid into a second set of wells of the array that lie perpendicularly to the first set of wells of the array;
- and
- introducing a fluid into a third set of wells of the array that lie perpendicularly to each of the first set of wells and the second set of wells of the array.
1 more element
A method for synthesizing or screening compounds comprising:
- introducing a fluid into a first set of inlets at a first surface of a three-dimensional array that comprises a plurality of wells;
- and
- introducing a fluid into a second set of inlets at a second surface of the three-dimensional array,
- wherein the first surface of the three-dimensional array lies adjacent to the second surface of the three-dimensional array.
1 more element
A method for synthesizing or analyzing compounds comprising:
- introducing a fluid through a first set of openings in a first set of side walls in an array;
- rotating the array by an angle;
- and
- introducing a fluid through a second set of openings in a second set of side walls in the array.
1 more element
Dependencies are inferred from the claim text.