Diagnosis and treatment of non-ulcer dyspepsia based on hypothalamic-pituitary-adrenal axis abnormallity
OwnerTimothy Garard Dinan, Paul William Napoleon Keelinginventors
Life of this patent
Estimating the term…
Abstract
An in vitromethod and a kit for the diagnosis of non-ulcer dyspepsia (NUD) in a subject suspected of having NUD, comprises identifying in the subject a dysfunction of corticotropin releasing hormone (CRH) receptors characterised by the subject's response to CRH-induced adrenocorticotropic hormone (ACTH) production by estimating the level of ACTH in a sample of blood or a blood fraction obtained from said subject relative to a control. The method can be used to diagnose NUD in patients who are infected with Helicobacter pylori and those who are free of such infection.
Claims8
An in vitro method for the diagnosis of non-ulcer dyspepsia (NUD) in a subject suspected of having NUD, which method comprises identifying in said subject a dysfunction of corticotropin releasing hormone (CRH) receptors characterised by the subject's response to CRH-induced adrenocorticotropic hormone (ACTH) production by estimating an increased level of ACTH in a sample of blood or a blood fraction obtained from said subject relative to a control.
Use of a CRF(1) receptor antagonist in the manufacture of a medicament for use in the treatment of non-ulcer dyspepsia.
Dependencies are inferred from the claim text.