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US 2003/0170728 A1Published application
Method and kit for detecting, or determining the quantity of, metabolites of fentanyl and metabolites of fentanyl analogs
AssigneeRandox Laboratories Limited
InventorsRobert Ivan McConnell, Elouard Benchikh, Stephen Peter Fitzgerald, John Victor Lamont
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Abstract
The invention provides an immunogen comprising a hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with at least one structural epitope of metabolites of fentanyl and of metabolites of fentanyl analogs.
Claims50
An immunogen of the formula:
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- wherein Z1 is slected from the group consisting of a crosslinker coupled to an antigenicity-conferring carrier material and hydrogen;
- Z4 is selected from the group consisting of N-phenethyl, a crosslinker coupled to an antigenicity-conferring carrier material and
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- wherein Z2 is a crosslinker coupled to an antigenicity-conferring carrier material at an ortho, a meta or a para position,
- with the provisos that, when Z1 is hydrogen, Z4 is selected from the group consisting of the crosslinker coupled to an antigenicity-conferring carrier material and
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- wherein Z2 is the crosslinker coupled to an antigenicity-conferring carrier material at an ortho, a meta or a para position;
- and, when Z4 is N-phenethyl, Z1 is a crosslinker coupled to an antigenicity-conferring carrier material, the crosslinker not being —COOH.
6 more elements
A conjugate of the formula:
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- wherein Z1 is selected from the group consisting of a crosslinker covalently bonded to a labelling agent which is detectable, and hydrogen;
- Z4 is selected from the group consisting of N-phenethyl, a crosslinker covalently bonded to a labelling agent which is detectable and
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- wherein Z2 is a crosslinker covalently bonded to a labelling agent which is detectable at an ortho, a meta or a para position,
- with the provisos that, when Z1 is hydrogen, Z4 is selected from the group consisting of the crosslinker covalently bonded to a labelling agent which is detectable and
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- wherein Z2 is the crosslinker covalently bonded to a labelling agent which is detectable at an ortho, a meta or a para position;
- and, when Z4 is N-phenethyl, Z1 is a crosslinker covalently bonded to a labelling agent which is detectable, the crosslinker not being —COOH.
6 more elements
Dependencies are inferred from the claim text.