Peptides sequences comprising one or several protein binding units of the ena/vasp family and the uses thereof
OwnerJulie Fradelizi, Evelyne Friederich +2inventors
InventorsJulie Fradelizi, Evelyne Friederich, Roy M Golsteyn, Daniel Louvard
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Abstract
The invention concerns the use of proteins or peptides comprising one or several protein binding units of the Ena/VASP family, said proteins or peptides not binding with the Arp2/3 protein complex, in particular fragments of the ActA protein of Listeria monocytogenes, or proteins of the zyxin family, for preparing reagents for use in implementing a process detecting and screening molecules having an inhibiting or stimulating effect on the formation of actin cytoskeleton.
Claims17
Use of proteins or peptides comprising one or more units binding to proteins of the Ena/VASP family, said proteins or peptides not binding with the Arp2/3 protein complex, and being capable of inducing actin polymerisation in vitro, for the preparation of reagents which can be used within the scope of the implementation of a process of detecting or screening molecules having an effect of inhibition or stimulation on the formation of the actin cytoskeleton.
Dependencies are inferred from the claim text.