US 2003/0170721 A1 · Secreted and transmembrane polypeptides and nucleic acids encoding the same

Secreted and transmembrane polypeptides and nucleic acids encoding the same

AssigneeGenentech, Inc.

InventorsAvi J. Ashkenazi, Kevin P. Baker, David A. Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Ivar J. Kljavin, Jennie P. Mather, Mary A. Napier, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Zemin Zhang

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Abstract

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Claims39

Dependent claims

Isolated nucleic acid having at least 80% nucleic acid sequence identity to a nucleotide sequence that encodes an amino acid sequence selected from the group consisting of the amino acid sequence shown in FIG. 2 (SEQ ID NO:

4), FIG. 4 (SEQ ID NO:
9), FIG. 6 (SEQ ID NO:
11), FIG. 8 (SEQ ID NO:
13), FIG. 10 (SEQ ID NO:
15), FIG. 12 (SEQ ID NO:
17), FIG. 14 (SEQ ID NO:
22), FIG. 16 (SEQ ID NO:
24), FIG. 18 (SEQ ID NO:
29), FIG. 20 (SEQ ID NO:
32), FIG. 22 (SEQ ID NO:
39), FIG. 24 (SEQ ID NO:
41), FIG. 26 (SEQ ID NO:
52), FIG. 28 (SEQ ID NO:
54), FIG. 30 (SEQ ID NO:
56), FIG. 32 (SEQ ID NO:
58), FIG. 34 (SEQ ID NO:
63), FIG. 36 (SEQ ID NO:
65), FIG. 38 (SEQ ID NO:
73), FIG. 40 (SEQ ID NO:
78), FIG. 42 (SEQ ID NO:
80), FIG. 44 (SEQ ID NO:
84), FIG. 46 (SEQ ID NO:
86), FIG. 48 (SEQ ID NO:
91), FIG. 50 (SEQ ID NO:
99), FIG. 52 (SEQ ID NO:
104), FIG. 54 (SEQ ID NO:
106), FIG. 56 (SEQ ID NO:
108), FIG. 58 (SEQ ID NO:
110), FIG. 60 (SEQ ID NO:
115), FIG. 62 (SEQ ID NO:
121), FIG. 64 (SEQ ID NO:
126), FIG. 66 (SEQ ID NO:
128), FIG. 68 (SEQ ID NO:
130), FIG. 70 (SEQ ID NO:
132), FIG. 72 (SEQ ID NO:
137) and FIG. 74 (SEQ ID NO:
139).

34 more elements

Isolated nucleic acid having at least 80% nucleic acid sequence identity to:

(a) a nucleotide sequence encoding the polypeptide shown in FIG. 2 (SEQ ID NO:
4), FIG. 4 (SEQ ID NO:
9), FIG. 6 (SEQ ID NO:
11), FIG. 8 (SEQ ID NO:
13), FIG. 10 (SEQ ID NO:
15), FIG. 12 (SEQ ID NO:
17), FIG. 14 (SEQ ID NO:
22), FIG. 16 (SEQ ID NO:
24), FIG. 18 (SEQ ID NO:
29), FIG. 20 (SEQ ID NO:
32), FIG. 22 (SEQ ID NO:
39), FIG. 24 (SEQ ID NO:
41), FIG. 26 (SEQ ID NO:
52), FIG. 28 (SEQ ID NO:
54), FIG. 30 (SEQ ID NO:
56), FIG. 32 (SEQ ID NO:
58), FIG. 34 (SEQ ID NO:
63), FIG. 36 (SEQ ID NO:
65), FIG. 38 (SEQ ID NO:
73), FIG. 40 (SEQ ID NO:
78), FIG. 42 (SEQ ID NO:
80), FIG. 44 (SEQ ID NO:
84), FIG. 46 (SEQ ID NO:
86), FIG. 48 (SEQ ID NO:
91), FIG. 50 (SEQ ID NO:
99), FIG. 52 (SEQ ID NO:
104), FIG. 54 (SEQ ID NO:
106), FIG. 56 (SEQ ID NO:
108), FIG. 58 (SEQ ID NO:
110), FIG. 60 (SEQ ID NO:
115), FIG. 62 (SEQ ID NO:
121), FIG. 64 (SEQ ID NO:
126), FIG. 66 (SEQ ID NO:
128), FIG. 68 (SEQ ID NO:
130), FIG. 70 (SEQ ID NO:
132), FIG. 72 (SEQ ID NO:
137) or FIG. 74 (SEQ ID NO:
139), lacking its associated signal peptide;
(b) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
4), FIG. 4 (SEQ ID NO:
9), FIG. 6 (SEQ ID NO:
11), FIG. 8 (SEQ ID NO:
13), FIG. 10 (SEQ ID NO:
15), FIG. 12 (SEQ ID NO:
17), FIG. 14 (SEQ ID NO:
22), FIG. 16 (SEQ ID NO:
24), FIG. 18 (SEQ ID NO:
29), FIG. 20 (SEQ ID NO:
32), FIG. 22 (SEQ ID NO:
39), FIG. 24 (SEQ ID NO:
41), FIG. 26 (SEQ ID NO:
52), FIG. 28 (SEQ ID NO:
54), FIG. 30 (SEQ ID NO:
56), FIG. 32 (SEQ ID NO:
58), FIG. 34 (SEQ ID NO:
63), FIG. 36 (SEQ ID NO:
65), FIG. 38 (SEQ ID NO:
73), FIG. 40 (SEQ ID NO:
78), FIG. 42 (SEQ ID NO:
80), FIG. 44 (SEQ ID NO:
84), FIG. 46 (SEQ ID NO:
86), FIG. 48 (SEQ ID NO:
91), FIG. 50 (SEQ ID NO:
99), FIG. 52 (SEQ ID NO:
104), FIG. 54 (SEQ ID NO:
106), FIG. 56 (SEQ ID NO:
108), FIG. 58 (SEQ ID NO:
110), FIG. 60 (SEQ ID NO:
115), FIG. 62 (SEQ ID NO:
121), FIG. 64 (SEQ ID NO:
126), FIG. 66 (SEQ ID NO:
128), FIG. 68 (SEQ ID NO:
130), FIG. 70 (SEQ ID NO:
132), FIG. 72 (SEQ ID NO:
137) or FIG. 74 (SEQ ID NO:
139), with its associated signal peptide;
or
(c) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
4), FIG. 4 (SEQ ID NO:
9), FIG. 6 (SEQ ID NO:
11), FIG. 8 (SEQ ID NO:
13), FIG. 10 (SEQ ID NO:
15), FIG. 12 (SEQ ID NO:
17), FIG. 14 (SEQ ID NO:
22), FIG. 16 (SEQ ID NO:
24), FIG. 18 (SEQ ID NO:
29), FIG. 20 (SEQ ID NO:
32), FIG. 22 (SEQ ID NO:
39), FIG. 24 (SEQ ID NO:
41), FIG. 26 (SEQ ID NO:
52), FIG. 28 (SEQ ID NO:
54), FIG. 30 (SEQ ID NO:
56), FIG. 32 (SEQ ID NO:
58), FIG. 34 (SEQ ID NO:
63), FIG. 36 (SEQ ID NO:
65), FIG. 38 (SEQ ID NO:
73), FIG. 40 (SEQ ID NO:
78), FIG. 42 (SEQ ID NO:
80), FIG. 44 (SEQ ID NO:
84), FIG. 46 (SEQ ID NO:
86), FIG. 48 (SEQ ID NO:
91), FIG. 50 (SEQ ID NO:
99), FIG. 52 (SEQ ID NO:
104), FIG. 54 (SEQ ID NO:
106), FIG. 56 (SEQ ID NO:
108), FIG. 58 (SEQ ID NO:
110), FIG. 60 (SEQ ID NO:
115), FIG. 62 (SEQ ID NO:
121), FIG. 64 (SEQ ID NO:
126), FIG. 66 (SEQ ID NO:
128), FIG. 68 (SEQ ID NO:
130), FIG. 70 (SEQ ID NO:
132), FIG. 72 (SEQ ID NO:
137) or FIG. 74 (SEQ ID NO:
139), lacking its associated signal peptide.

112 more elements

An isolated polypeptide having at least 80% amino acid sequence identity to:

(a) the polypeptide shown in FIG. 2 (SEQ ID NO:
4), FIG. 4 (SEQ ID NO:
9), FIG. 6 (SEQ ID NO:
11), FIG. 8 (SEQ ID NO:
13), FIG. 10 (SEQ ID NO:
15), FIG. 12 (SEQ ID NO:
17), FIG. 14 (SEQ ID NO:
22), FIG. 16 (SEQ ID NO:
24), FIG. 18 (SEQ ID NO:
29), FIG. 20 (SEQ ID NO:
32), FIG. 22 (SEQ ID NO:
39), FIG. 24 (SEQ ID NO:
41), FIG. 26 (SEQ ID NO:
52), FIG. 28 (SEQ ID NO:
54), FIG. 30 (SEQ ID NO:
56), FIG. 32 (SEQ ID NO:
58), FIG. 34 (SEQ ID NO:
63), FIG. 36 (SEQ ID NO:
65), FIG. 3 8 (SEQ ID NO:
73), FIG. 40 (SEQ ID NO:
78), FIG. 42 (SEQ ID NO:
80), FIG. 44 (SEQ ID NO:
84), FIG. 46 (SEQ ID NO:
86), FIG. 48 (SEQ ID NO:
91), FIG. 50 (SEQ ID NO:
99), FIG. 52 (SEQ ID NO:
104), FIG. 54 (SEQ ID NO:
106), FIG. 56 (SEQ ID NO:
108), FIG. 58 (SEQ ID NO:
110), FIG. 60 (SEQ ID NO:
115), FIG. 62 (SEQ ID NO:
121), FIG. 64 (SEQ ID NO:
126), FIG. 66 (SEQ ID NO:
128), FIG. 68 (SEQ ID NO:
130), FIG. 70 (SEQ ID NO:
132), FIG. 72 (SEQ ID NO:
137) or FIG. 74 (SEQ ID NO:
139), lacking its associated signal peptide;
(b) an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
4), FIG. 4 (SEQ ID NO:
9), FIG. 6 (SEQ ID NO:
11), FIG. 8 (SEQ ID NO:
13), FIG. 10 (SEQ ID NO:
15), FIG. 12 (SEQ ID NO:
17), FIG. 14 (SEQ ID NO:
22), FIG. 16 (SEQ ID NO:
24), FIG. 18 (SEQ ID NO:
29), FIG. 20 (SEQ ID NO:
32), FIG. 22 (SEQ ID NO:
39), FIG. 24 (SEQ ID NO:
41), FIG. 26 (SEQ ID NO:
52), FIG. 28 (SEQ ID NO:
54), FIG. 30 (SEQ ID NO:
56), FIG. 32 (SEQ ID NO:
58), FIG. 34 (SEQ ID NO:
63), FIG. 36 (SEQ ID NO:
65), FIG. 38 (SEQ ID NO:
73), FIG. 40 (SEQ ID NO:
78), FIG. 42 (SEQ ID NO:
80), FIG. 44 (SEQ ID NO:
84), FIG. 46 (SEQ ID NO:
86), FIG. 48 (SEQ ID NO:
91), FIG. 50 (SEQ ID NO:
99), FIG. 52 (SEQ ID NO:
104), FIG. 54 (SEQ ID NO:
106), FIG. 56 (SEQ ID NO:
108), FIG. 58 (SEQ ID NO:
110), FIG. 60 (SEQ ID NO:
115), FIG. 62 (SEQ ID NO:
121), FIG. 64 (SEQ ID NO:
126), FIG. 66 (SEQ ID NO:
128), FIG. 68 (SEQ ID NO:
130), FIG. 70 (SEQ ID NO:
132), FIG. 72 (SEQ ID NO:
137) or FIG. 74 (SEQ ID NO:
139), with its associated signal peptide;
or
(c) an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
4), FIG. 4 (SEQ ID NO:
9), FIG. 6 (SEQ ID NO:
11), FIG. 8 (SEQ ID NO:
13), FIG. 10 (SEQ ID NO:
15), FIG. 12 (SEQ ID NO:
17), FIG. 14 (SEQ ID NO:
22), FIG. 16 (SEQ ID NO:
24), FIG. 18 (SEQ ID NO:
29), FIG. 20 (SEQ ID NO:
32), FIG. 22 (SEQ ID NO:
39), FIG. 24 (SEQ ID NO:
41), FIG. 26 (SEQ ID NO:
52), FIG. 28 (SEQ ID NO:
54), FIG. 30 (SEQ ID NO:
56), FIG. 32 (SEQ ID NO:
58), FIG. 34 (SEQ ID NO:
63), FIG. 36 (SEQ ID NO:
65), FIG. 38 (SEQ ID NO:
73), FIG. 40 (SEQ ID NO:
78), FIG. 42 (SEQ ID NO:
80), FIG. 44 (SEQ ID NO:
84), FIG. 46 (SEQ ID NO:
86), FIG. 48 (SEQ ID NO:
91), FIG. 50 (SEQ ID NO:
99), FIG. 52 (SEQ ID NO:
104), FIG. 54 (SEQ ID NO:
106), FIG. 56 (SEQ ID NO:
108), FIG. 58 (SEQ ID NO:
110), FIG. 60 (SEQ ID NO:
115), FIG. 62 (SEQ ID NO:
121), FIG. 64 (SEQ ID NO:
126), FIG. 66 (SEQ ID NO:
128), FIG. 68 (SEQ ID NO:
130), FIG. 70 (SEQ ID NO:
132), FIG. 72 (SEQ ID NO:
137) or FIG. 74 (SEQ ID NO:
139), lacking its associated signal peptide.

112 more elements

Dependencies are inferred from the claim text.