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US 2003/0170713 A1Published application
Method of detecting androgen-regulated gene
AssigneeThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
InventorsShiv Srivastava, Judd W. Moul, Linda L. Xu, Takehiko Segawa
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Abstract
This invention relates to androgen-regulated nucleic acids, a polynucleotide array containing these androgen-regulated nucleic acids, and methods of using the polynucleotide array in the diagnosis and prognosis of prostate cancer.
Claims24
A polynucleotide array comprising:
- (a) a planar, non-porous solid support having at least a first surface;
- and
- (b) a first set of polynucleotide probes attached to the first surface of the solid support, wherein the first set of polynuceotide probes comprises polynucleotide sequences derived from genes that are up-regulated or down-regulated in response to androgen.
An isolated nucleic acid molecule selected from:
- (a) the polynucleotide sequence of SEQ ID NO:2;
- and
- (b) an isolated nucleic acid molecule that encodes a polypeptide having an amino acid sequence of SEQ ID NO:3.
A method of detecting prostate cancer in a patient, comprising:
- (a) detecting mRNA corresponding to the polynucleotide sequence of SEQ ID NO:2 in a biological sample from the patient;
- and
- (b) correlating the amount of mRNA corresponding to the polynucleotide sequence of SEQ ID NO:2 in the sample with the presence of prostate cancer in the patient.
An isolated polypeptide, comprising the amino acid sequence of SEQ ID NO:3.
Dependencies are inferred from the claim text.