Method and/or system for analyzing biological samples using a computer system
AssigneeVysis, Inc., a Corporation of the State of Delaware
InventorsJames R. Piper, Ian Poole, Thomas Richard Lorch
Life of this patent
Estimating the term…
Abstract
A method and/or system for making determinations regarding samples from biologic sources. A computer implemented method and/or system can be used to automate parts of the analysis.
Claims61
A method of analyzing biological samples for determinable properties using a computer system comprising:
- capturing an image of said sample into a computer system;
- using said computer system, placing tile outlines over said image according to a placement process;
- using said computer system, analyzing said image by scoring detectable characteristics of said image within one or more of said tile outlines;
- and
- using said computer system, preparing an output from scored detectable characteristics of said image.
A method of analyzing a biological sample image comprising:
- determining a plurality of subareas over said image;
- in each subarea, computing a ratio from detectable signals;
- computing an original histogram of said ratios;
- computing a normal-corrected histogram of said ratios;
- and
- from said normal-corrected histogram, estimating a ratio value for one or more cells in said sample.
The method according to claim 44 wherein said plurality of subareas comprise a plurality of areas containing separated cells.
The method according to claim 44 wherein said plurality of subareas comprise a plurality of outlines placed in a regular grid.
The method according to claim 44 wherein said plurality of subareas comprise a plurality of targeted outlines placed by a placement method.
A method of analyzing a biological sample image comprising:
- determining a plurality of subareas over said image;
- in each subarea, determining a data set of one or more detectable characteristics;
- and
- using an expectation maximization method to estimate an output from said scored detectable characteristics.
A system for analyzing biologic samples comprising:
- an information processor for handling digital data;
- data storage for storing digital data, including captured image data;
- a logic module able to analyze said captured image data to estimate observable features of said data;
- and
- a set of user interfaces allowing a user to request analysis and/or set analysis parameters and/or review analyzed image data.
A system for analyzing biologic samples comprising:
- means for capturing digital image data from one or more biologic samples;
- means for storing digital image data;
- means for interacting with a user to receive user instructions and user review of image data;
- and
- means for logically analyzing said captured digital image data to estimate one or more observable parameters;
- and
- means for outputting estimated observable parameters.
Dependencies are inferred from the claim text.