Polymorphisms associated with hypertension

Allele-specific oligonucleotide that hybridizes to a sequence including a polymorphic site shown in Table 1 or the complement thereof.

An isolated nucleic acid comprising a sequence of Table 1, column 8 or the complement thereof, wherein the polymorphic site within the sequence or its complement is occupied by a base other than the reference base show in Table 1, column 3.

A method of analyzing a nucleic acid, comprising:

• obtaining the nucleic acid from an individual;
• and
• determining a base occupying any one of the polymorphic sites shown in Table 1 or other polymorphic sites in equilibrium dislinkage therewith.

A method of diagnosing a phenotype comprising:

• determining which polymorphic form(s) are present in a sample from a subject at one or more polymorphic sites shown in Table 1;
• diagnosing the presence of a phenotype correlated with the form(s) in the subject.

A method of screening for a polymorphic site suitable for diagnosing a phenotype, comprising:

• identifying a polymorphic site linked to a polymorphic site shown in Table 1, wherein a polymorphic form of the polymorphic site shown in Table 1 has been correlated with a phenotype;
• and
• determining haplotypes in a population of individuals to indicate whether the linked polymorphic site has a polymorphic form in equlibrium dislinkage with the polymorphic form correlated with the phenotype.

A computer-readable storage medium for storing data for access by an application program being executed on a data processing system, comprising:

• a data structure stored in the computer-readable storage medium, the data structure including information resident in a database used by the application program and including:
• a plurality of records, each record of the plurality comprising information identifying a polymorphisms shown in Table 1.

A signal carrying data for access by an application program being executed on a data processing system, comprising:

• a data structure encoded in the signal, said data structure including information resident in a database used by the application program and including:
• a plurality of records, each record of the plurality comprising information identifying a polymorphism shown in Table 1