Detection and treatment of infections with immunoconjugates
OwnerDavid M. Goldenberginventor
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Abstract
A method of targeting a diagnostic or therapeutic agent to a focus of infection comprises injecting a patient infected with a pathogen parenterally with an antibody conjugate which specifically binds to an accessible epitope of the pathogen or of a pathogen-associated antigen accreted at the focus of infection, the antibody conjugate further comprising a bound diagnostic or therapeutic agent for detecting, imaging or treating the infection. Polyspecific composite conjugates enhance the efficacy of the method, which is especially useful for treating infections that are refractory towards systemic chemotherapy.
Claims29
A method of targeting a diagnostic or therapeutic agent to a focus of infection, which comprises injecting a patient infected with a pathogen parenterally with an antibody conjugate which specifically binds to an accessible epitope of said pathogen or of a pathogen-associated antigen accreted at said focus of infection, said antibody conjugate further comprising a bound diagnostic or therapeutic agent for detecting, imaging or treating said infection.
The method of claim, 1, wherein said antibody conjugate is a polyspecific conjugate which specifically binds to a plurality of accessible epitopes of said pathogen or antigen.
An antibody conjugate for targeting a focus of infection, comprising an antibody or antibody fragment which binds to an epitope on a single species of pathogen or an antigen derived therefrom, said antibody or antibody fragment being conjugated to at least one diagnostic or therapeutic agent.
An antibody conjugate for targeting a focus of infection, comprising an immunoreactive composite of a plurality of chemically linked antibodies or antibody fragments which bind to a plurality of epitopes on a single species of pathogen or an antigen derived therefrom, said composite being conjugated to at least one diagnostic or therapeutic agent.
Dependencies are inferred from the claim text.