Immunocellular receptors related to neurological disorders and therapeutic uses thereof
AssigneePresident and Fellows of Harvard College
InventorsCarla J. Shatz, Joshua Syken
Life of this patent
Estimating the term…
Abstract
Class I major histocompatibility complex, is required in the activity-dependent refinement and plasticity of connections in the developing and adult central nervous system, demonstrating that molecules can perform critical roles in both systems. Similarities in the cellular signaling mechanisms of the immune and nervous systems provide for development of therapeutic and diagnostic agents in abnormal neuronal cellular function.
Claims56
An isolated neuronal nucleic acid sequence or fragment thereof coding for an immune related molecule.
A nucleic acid sequence that hybridizes under normal stringency conditions to a nucleic acid sequence or functional fragment thereof coding for a variant of an immune related molecule isolated from a neuronal cell.
A nucleic acid sequence that hybridizes under high stringency conditions to a nucleic acid sequence or functional fragment thereof coding for a variant of an immune related molecule isolated from a neuronal cell.
A method for diagnosing an individual suffering from or susceptible to a neural disorder or defect, comprising:
- isolating a neuronal cell;
- and,
- identifying an immune related molecule in the neuronal cell;
- and,
- comparing the level of expression of the neuronal immune related molecule to the level of the immune related molecule in an immune cell;
- and,
- correlating the expression of the neuronal immune molecule with a neural defect or disorder.
A method for treating a mammal against a neural disorder, comprising:
- administering to the mammal or neuronal cells thereof an effective amount of a nucleic acid sequence coding for an immune related molecule or fragment thereof.
A method for identifying a compound that interacts with an immune related gene, variants or fragments thereof, or oligopeptides, comprising
- contacting a candidate agent with the immune related gene, an allele or fragment thereof, or expression product thereof, and
- performing a detection step to detect interaction between said immune related gene, an allele or fragment thereof, or expression product thereof.
A method for identifying compounds that interact with an immune related gene, variants, or fragments thereof, or expression products thereof, comprising:
- providing an immune related gene, allele or fragment thereof, or oligopeptide expression product thereof;
- and,
- contacting a candidate compound with the immune related gene, allele or fragment or oligopeptide;
- and
- detecting interaction of the candidate compound with the immune related gene, allele or fragment or oligopeptide.
A kit comprising a immune related gene, variant or fragment thereof, or expression product thereof.
A method for identifying one or more genes that mediate neural disorders in a mammal comprising:
- hybridizing an isolated nucleic acid sequence with an immune related nucleic acid probe to form a hybridized molecule;
- and
- detecting sequences hybridized to the probe.
Dependencies are inferred from the claim text.