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US 2003/0170687 A1Published application
Sensor for use in testing biological, biochemical, chemical or environmental samples
AssigneeDuke University
InventorsAshutosh Chilkoti, Nidhi Nath, Wolfgang Frey
Life of this patent
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Abstract
Disclosed are sensors for use in testing biological, biochemical, chemical or environmental samples, and methods of making and using the same.
Claims24
A sensor for use in testing biological, biochemical, chemical or environmental samples, said sensor comprising:
- (a) an optically transparent substrate having a first surface and a second surface;
- (b) optionally, a layer of a first functionalized material disposed over at least a portion of said first surface of said substrate;
- (c) a monolayer or sub-monolayer of a metallic material disposed over at least a portion of said first surface of said substrate or, when present, said layer of a first functionalized material, said monolayer being optically transparent and exhibiting colloidal surface plasmon resonance;
- (d) optionally, a layer of a second functionalized material disposed over at least a portion of said monolayer or sub-monolayer of metallic material;
- and
- (e) a reactive substance disposed over at least a portion of said monolayer or sub-monolayer of a metallic material or, when present, said layer of a second functionalized material, wherein said reactive substance interacts with a predetermined substance present in said biological, biochemical, chemical or environmental sample.
3 more elements
A sensor for use in testing biological, biochemical, chemical or environmental samples, said sensor comprising:
- (a) an optically transparent substrate having a first surface and a second surface;
- (b) optionally, a layer of a first functionalized material disposed over at least a portion of said first surface of said substrate;
- (c) at least one nanoparticle of a metallic material on said first surface of said substrate or, when present, said layer of a first functionalized material, wherein said nanoparticle is optically transparent and exhibits surface plasmon resonance;
- (d) optionally, a layer of a second functionalized material disposed over at least a portion of said nanoparticle of metallic material;
- and
- (e) a reactive substance disposed over at least a portion of said nanoparticle of a metallic material or, when present, said layer of a second functionalized material, wherein said reactive substance interacts with a predetermined substance present in said biological, biochemical, chemical or environmental sample.
3 more elements
Dependencies are inferred from the claim text.