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AssigneeNeurogenetics, Inc.
InventorsRudolph E. Tanzi, Kenneth David Becker, Gonul Velicelebi, Kathryn J. Elliott, Xin Wang, Lars Bertram, Aleister J. Saunders, Deborah Lynne Blacker
Estimating the term…
Genetic markers associated with Alzheimer's disease are provided. Also provided are methods of determining the presence or absence in a subject of one or more polymorphisms associated with Alzheimer's disease and methods of determining the level of risk for Alzheimer's disease in a subject. Further provided are nucleic acid compositions and kits for use in determining the presence or absence in a subject of one or more polymorphisms associated with Alzheimer's disease and kits for determining the level of risk for Alzheimer's disease in a subject.
A method for detecting the presence or absence in a subject of a polymorphism associated with Alzheimer's disease, comprising analyzing chromosome 10 of the subject for a polymorphism associated with Alzheimer's disease.
A method for detecting the presence or absence in a subject of two or more polymorphisms associated with Alzheimer's disease, comprising analyzing chromosome 10 of the subject for two or more polymorphisms associated with Alzheimer's disease, wherein at least one polymorphism is an allele of D10S583.
A method for indicating a predisposition to or the occurrence of Alzheimer's disease in a subject, comprising:
A method for confirming a phenotypic diagnosis of Alzheimer's disease in a subject, comprising:
A method for predicting a response of a subject to a drug used to treat Alzheimer's disease, comprising:
A method of treating a subject manifesting an Alzheimer's disease phenotype, comprising:
A method for identifying a gene as a candidate Alzheimer's disease gene, comprising selecting a gene on chromosome 10q that is or encodes a product that has one or more properties which relate to one or more phenomena in neurodegenerative disease and thereby identifying a candidate Alzheimer's disease gene.
A method for identifying a polymorphism associated with Alzheimer's disease, comprising:
A method for identifying a polymorphism associated with Alzheimer's disease, comprising analyzing a polymorphism on chromosome 10 for association with Alzheimer's disease, wherein the polymorphism is located in the region of 10q22, 10q23, 10q24, 10q25 or 10q26.
A method for identifying a polymorphism associated with Alzheimer's disease, comprising analyzing a polymorphism on chromosome 10 for association with Alzheimer's disease, wherein the polymorphism is located in the region of 10q22, 10q23 or 10q24.
A method for identifying a polymorphism associated with Alzheimer's disease comprising, analyzing a polymorphism on chromosome 10 for association with Alzheimer's disease, wherein the polymorphism is located is located about 30 cM around and including D10S583, or about 20 cM around and including D10S583, or about 15 cM around and including D10S583, or about 12 cM around and including D10S583, or about 10 cM around and including D10S583.
A combination, comprising:
A kit, comprising:
A kit, comprising:
A kit, comprising:
A kit, comprising:
A kit, comprising:
A combination comprising:
A method for detecting the presence or absence in a subject of polymorphisms associated with Alzheimer's disease, comprising analyzing chromosome 10 of the subject for two or more polymorphisms associated with Alzheimer's disease, wherein at least two of the polymorphisms are associated with different AD DNA segments.
A method of determining the level of risk for Alzheimer's disease in a subject, comprising:
A method for detecting the presence or absence in a subject of a combination of polymorphisms associated with Alzheimer's disease, comprising analyzing chromosome 10 of the subject for a combination of polymorphisms associated with Alzheimer's disease.
Dependencies are inferred from the claim text.