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OwnerKen Sasaki, Robin E. Harkness +3inventors
InventorsKen Sasaki, Robin E. Harkness, Sheena M. Loosmore, Pele Chong, Michel H. Klein
Estimating the term…
An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, having a molecular mass of about 200 kDa, is provided. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.
An isolated and purified outer membrane protein of a Moraxella strain having an apparent molecular mass of about 200 kDa, as determined by SDS-PAGE or a fragment or an analog thereof.
A purified and isolated nucleic acid molecule encoding an outer membrane protein of a strain of Moraxella having a molecular mass of about 200 kDa, as determined by SDS-PAGE, or a fragment or an analog of the outer membrane protein.
A purified and isolated nucleic acid molecule having a sequence selected from the group consisting of:
A peptide having no less than six amino acids and no more than 150 amino acids and containing an amino acid sequence corresponding to a portion only of an outer membrane protein of a strain of Moraxella having a molecular mass of about 200 kDa, as determined by SDS-PAGE, or a fragment or of an analog of the outer membrane protein.
An immunogenic composition, comprising at least one active component selected from the group consisting of:
Dependencies are inferred from the claim text.